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Eosinophil Activation in Ulcerative Colitis
http://hdl.handle.net/10069/16009
http://hdl.handle.net/10069/160096ba83ce0-20b6-40b8-bd0f-3cfcdad981c5
名前 / ファイル | ライセンス | アクション |
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acta39_04_07_t.pdf (443.7 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-03-13 | |||||
タイトル | ||||||
タイトル | Eosinophil Activation in Ulcerative Colitis | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ulcerative colitis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | eosinophil cationic protein | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | hypodense eosinophi | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Kanzaki, Shinichiro
× Kanzaki, Shinichiro× Makiyama, Kazuya× Itsuno, Minoru× Yamasaki, Yoshiyuki× Oda, Hidetoshi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | To evaluate the activity level of eosinophils in patients with ulcerative colitis (UC), we analyzed peripheral blood eosinophil counts, serum levels of eosinophil cationic protein (ECP) and the percentage of hypodense eosinophils among all eosinophils in peripheral blood. Patients with active UC had significantly higher serum ECP levels and eosinophil counts, compared with patients in remission and healthy controls. Serum ECP levels correlated positively with eosinophil counts. In patients who could be followed from the active stage of UC to remission, ECP decreased significantly over time and eventually reached approximately normal levels, while eosinophil counts showed no significant change. The mean percentage of hypodense eosinophils (specific gravity < 1.082 g/ml) in peripheral blood was 5% or less in patients in remission and healthy controls, but it was 31.7 % in patients with active UC. These results suggest that eosinophils are activated in patients with UC, and that they are involved in injury to the colorectal mucosa by inducing the release of cytotoxic proteins such as ECP. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 39, 号 4, p. 40-44, 発行日 1994-12-15 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00040-P00044 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 1994, 39(4), p.40-44 |