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Phenotype and cytokine production of Lamina Propria Mononuclear Cells from Endoscopic Biopsy Specimens in Untreated Patients with Ulcerative Colitis
http://hdl.handle.net/10069/16012
http://hdl.handle.net/10069/1601224e8e86a-c372-4305-ad3e-2f8b4da97e66
名前 / ファイル | ライセンス | アクション |
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acta39_04_10_t.pdf (665.1 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-03-13 | |||||
タイトル | ||||||
タイトル | Phenotype and cytokine production of Lamina Propria Mononuclear Cells from Endoscopic Biopsy Specimens in Untreated Patients with Ulcerative Colitis | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Interleukin 1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Interleukin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Lamina Propria | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Mononuclear Cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Ulcerative Colitis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Nakamuta, Koji
× Nakamuta, Koji× Makiyama, Kazuya× Senju, Masahiro× Oda, Hidetoshi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The phenotype of, and the production of interleukinl-β(I L-1β)and interleukin 6(IL、-6)by lamina propria mononuclear cells (LPMNC) were studied in 25 patients with ulcerative colitis (UC) (11 with untreated active disease and 14 inactive disease), and 18 control subjects. The percentage of CD4+ cells, CD20+ cells, CD3+, CD25+ cells and CD3+, HLA-DR+ cells was significantly higher in patients with active UC than in control patients, however, the percentage of CD8+ cells was significantly lower in patients with active UC than in patients with inactive UC and controls. IL-1 β was detected in nine of the ll patients(82%) with active UC but in only two of the 14 patients (14 %) with inactive UC and three of the 18 control subjects (17 %). The amount of IL-6 in patients with active UC was significantly higher than in patients with inactive UC and in controls. These results suggest that IL-1β and IL-6 mediate immune responses, and may be associated with inflammation and the etiopathogenesis of UC. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 39, 号 4, p. 55-60, 発行日 1994-12-15 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00055-P00060 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 1994, 39(4), p.55-60 |