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Regulation of Colonic Mucosal Blood Flow by Exogenous Ecosanoids in the Rat
http://hdl.handle.net/10069/16016
http://hdl.handle.net/10069/160160cdaad84-2c0b-40b4-add4-a5aff47a2851
名前 / ファイル | ライセンス | アクション |
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acta39_04_14_t.pdf (666.5 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-03-13 | |||||
タイトル | ||||||
タイトル | Regulation of Colonic Mucosal Blood Flow by Exogenous Ecosanoids in the Rat | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Prostaglandins | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | inflammatory bowel disease | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | colonic vascularization | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | thromboxane A 2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cyclic adenosine monophosphate | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Yoshida, Noboru
× Yoshida, Noboru× Makiyama, Kazuya× Hoshiko, Tatsuhide |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We measured colonic mucosal blood flow using a reflectance spectrophotometry in Wistar rats during and after continuous injection of prostaglandins (PGs: PGE1, PGE2 and PGI2), as vasodilators, and thromboxane A2 (TXA2) as a vasoconstrictor. Administration of PGs increased colonic mucosal blood volume and oxyhemoglobin saturation of the colonic mucosal tissue, representing a parameter of mucosal oxygenation. The dose used did not change arterial blood pressure. These results suggest that PGs regulate colonic mucosal hemodynamics and oxygenation, and may thus act as cytoprotective substances. On the other hand, TXA2 injection diminished colonic mucosal blood flow compared with the same dose of PGI2 injection and acted against PGI2. Our results suggest that TXA2 and PGI2 regulate colonic mucosal hemodynamics. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 39, 号 4, p. 76-81, 発行日 1994-12-15 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00076-P00081 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 1994, 39(4), p.76-81 |