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Diagnostic Validity of Combining HTLV-1 Serology and Immunophenotyping in Adult T-Cell Leukemia
http://hdl.handle.net/10069/16067
http://hdl.handle.net/10069/1606711a28a73-1c53-4abc-8cd5-be44cdb84475
名前 / ファイル | ライセンス | アクション |
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acta41_03_11_t.pdf (880.0 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-03-13 | |||||
タイトル | ||||||
タイトル | Diagnostic Validity of Combining HTLV-1 Serology and Immunophenotyping in Adult T-Cell Leukemia | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | sensitivity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | specificity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | predictive value | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ATL | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | HTLV-1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | anti-HTLV-1 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Sugahara, Kazuyuki
× Sugahara, Kazuyuki× Tsuruda, Kazuto× Yamada, Yasuaki× Hirakata, Youichi× Atogami, Sunao× Sohda, Hisashi× Tsukazaki, Kunihiro× Tomonaga, Masao× Kamihira, Shimeru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Adult T-cell leukemia (ATL) is heterogeneous and sometimes equivocal to other T-cell neoplasms. Detecting anti- HTLV-1 antibodies is significant for a first screening not only for HTLV-1 infection but also for the HTLV-1-related disorders of ATL and TSP/HAM. The purpose of the present study was to investigate the diagnostic validity of HTLV-1 serology in ATL. The serologic results by a gelatin particle agglutination (PA) assay were highly sensitive (100%) and specific (99.5%) for the results of polymerase chain reaction (PCR) assay in 666 healthy blood donors who live in an area endemic for the HTLV-1 virus. Of 7,536 hospitalized patients, 189 patients with ATL were serologically screened. There were 1,140 patients (15.2%) infected by chance with HTLV-1, showing specificity, sensitivity, positive predictive value (PV), and negative PV of 84.3%, 100%, 14.2%, and 100%, respectively. Since the low positive PV (14.2%) was useless, we tried combining the anti-HTLV-1 assay with the immunophenotyping necessary for the diagnosis of lymphoid neoplasms. This combination gave nearly 100% positive and negative PV, and could prove to be useful in diagnosing ATL with the probability of 98%, especially for epidemiologic studies. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 41, 号 3-4, p. 66-70, 発行日 1996-12 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00066-P00070 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 1996, 41(3-4), p.66-70 |