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Proliferation Potentials of Human Intracranial Neoplasms Assessed with Ki-67 (MIB-1) Labeling Index and Argyrophilic Nucleolar Organizer Regions
http://hdl.handle.net/10069/16078
http://hdl.handle.net/10069/16078a3d33e5b-2dd2-41fb-bbf4-6eac9ad7268c
名前 / ファイル | ライセンス | アクション |
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acta42_01_08_t.pdf (908.3 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-03-13 | |||||
タイトル | ||||||
タイトル | Proliferation Potentials of Human Intracranial Neoplasms Assessed with Ki-67 (MIB-1) Labeling Index and Argyrophilic Nucleolar Organizer Regions | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Brain Neoplasm | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Ki-67 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Labeling Index | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Ag-NOR | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Histologic Grade | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Correlation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Survival | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Tokunaga, Yoshiharu
× Tokunaga, Yoshiharu× Khalid, Humayun× Hiura, Tsuyoshi× Shibata, Shobu |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | To evaluate the accuracy of the Ki-67 labeling index (LI) as an index of brain tumor proliferation, specimens of 303 intracranial neoplasms were examined for tumor proliferation potentials as assessed by MIB-1 (Ki-67 antigen) immunostaining and/or counting the argyrophilic nucleolar organizer regions (Ag-NORs). The Ki-67 LIs were higher in the histologically high grade tumors, i.e., the metastatic carcinomas, malignant lymphomas, glioblastomas, medulloblastomas, anaplastic astrocytomas, anaplastic oligodendrogliomas, anaplastic ependymomas, and anaplastic meningiomas compared to the histologically low grade tumors, i.e., the pilocytic astrocytomas, grade II astrocytomas, oligodendrogliomas, ependymomas, meningiomas other than those of the anaplastic variety, and pituitary adenomas. The number of Ag-NORs was not correlated with the tumor grade, and was inconsistent with the growth potential in some tumors. Moreover, in the consecutive sections of 87 tumors stained for both Ki-67 and Ag-NORs, the number of Ag-NORs did not correlate with the tumor Ki-67 LI in a regression analysis (r = 0.139). The patients with a high grade astrocytoma (anaplastic astrocytoma and glioblastoma) and a tumor Ki-67 LI > 10 had significantly shorter survival periods than those of the patients with a Ki-67 LI < 10 (p = 0.029). Our results thus suggest that Ki-67 is a potential marker of tumor growth activity and that the Ki-67 LI may be of use as an indicator of the prognosis of patients with brain tumor. The number of Ag-NORs may not always reflect the growth potential of some tumors. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 42, 号 1-2, p. 44-50, 発行日 1997-06-20 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00044-P00050 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 1997, 42(1-2), p.44-50 |