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Comparison between Prolonged Administration of Oral Etoposide and UFT Combined with Intravenous Cisplatin-based Chemotherapy in Postoperative Non-small Cell Lung Cancer: a Randomized Trial
http://hdl.handle.net/10069/16129
http://hdl.handle.net/10069/161290a087fb5-7d45-44df-b95d-f7ab83a890b8
名前 / ファイル | ライセンス | アクション |
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acta44_01_04_t.pdf (487.2 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-03-13 | |||||
タイトル | ||||||
タイトル | Comparison between Prolonged Administration of Oral Etoposide and UFT Combined with Intravenous Cisplatin-based Chemotherapy in Postoperative Non-small Cell Lung Cancer: a Randomized Trial | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | etoposide | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | UFT | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | postoperative chemotherapy | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Tagawa, Yutaka
× Tagawa, Yutaka× Ayabe, Hiroyoshi× Tomita, Masao× Matuzaki, Yasunori× Shibata, Koichiro× Tanaka, Koichi× Uchida, Yuzo× Ichimanda, Mitsutoshi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Oral administration of etoposide or UFT is generally used in outpatient treatment of non-small cell lung cancer (NSCLC) after surgery in Japan. We examined the effectiveness of etoposide and UFT with relation to disease-free survival, overall survival and toxicity in postoperative NSCLC patients. In this study, a total of 50 patients were randomized to receive either, 25mg/day of etoposide, on a 2 week cycle (Group I- 25 cases) or 300mg/day of UFT, continuous administration (Group II-25 cases), after a Mitomycin C, Cisplatin and Vindesine, intravenous (i.v.). Disease-free and overall survival were better in Group II with 20 complete cases than in Group I with 15 complete cases. Furthermore, Group II achieved better disease-free and overall survival rates than Group I with reference to stage IIIA and lymph node metastasis groups. There were no instances of severe toxicity in either group. Results of this study showed that prolonged oral administration of 25mg/day of etoposide is ineffective compared with oral UFT in NSCLC patients after surgical treatment. New randomized clinical trials of 50mg/day of etoposide will be necessary to determine usefulness and toxicity. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 44, 号 1-2, p. 24-28, 発行日 1999-06-23 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00024-P00028 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 1999, 44(1-2), p.24-28 |