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Cognitive Dysfunction, MRI Findings and Manganese Levels in Alcoholics
http://hdl.handle.net/10069/16227
http://hdl.handle.net/10069/16227a4e44f54-758f-4aa5-8e9e-e5ea2a3ed002
名前 / ファイル | ライセンス | アクション |
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acta47_03_12_t.pdf (1.1 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-03-13 | |||||
タイトル | ||||||
タイトル | Cognitive Dysfunction, MRI Findings and Manganese Levels in Alcoholics | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | alcoholism | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | liver cirrhosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | magnetic resonance imaging | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | manganese | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cognitive dysfunction | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Wechsler Adult Intelligence Scale-Revise d (WAIS-R) | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Itoh, Tsutomu
× Itoh, Tsutomu× Takahashi, Katsurou× Shimanaga, Masaki× Nakane, Yoshibumi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Alcoholic patients have been known to have brain atrophy and cognitive dysfunction. However,recent studies have reported bilateral signal hyperintensities of the globus pallidus on T1-weighted magnetic resonance imaging (MRI) in liver failure, findings that are typically associated with manganese intoxication. The present study compared brain atrophy on T1-weighted MRI, signal intensity ratios of the globus pallidus on T1-weighted MRI, whole blood manganese levels, and Wechsler Adult Intelligence Scale-Revised (WAIS-R) IQ parameters between alcoholics with and without liver cirrhosis, to investigate cognitive dysfunction, MRI findings and manganese levels in alcoholics. Pallidal hyperintensity was visually identified in 80% of alcoholic patients with liver cirrhosis. In addition, a significant correlation was seen between pallidal signal intensity (P.S.I.) ratio and blood manganese level. However, no significant correlations were found between pallidal signal intensity ratio and any of the WAIS-R parameters. These findings suggest that no direct connection exists between cognitive dysfunction and pallidal hyperintensity in alcoholic patients with liver cirrhosis. We confirmed that brain MRI in alcoholics could detect pallidal signal hyperintensity, suggesting severe liver dysfunction. In addition to diagnosis, brain MRI is useful for therapeutic psychoeducation to alcoholic patients with liver cirrhosis, visualizing the severe liver dysfunction. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 47, 号 3-4, p. 149-154, 発行日 2002-12-17 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00149-P00154 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 2002, 47(3-4), p.149-154 |