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Tyrphostin AG 1478 Accelerates Hydrogen Peroxide-Induced Apoptosis in A431 Cells
http://hdl.handle.net/10069/16254
http://hdl.handle.net/10069/162549945fabd-5399-4893-aae6-a9697c764610
名前 / ファイル | ライセンス | アクション |
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acta48_03_05_t.pdf (838.4 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-03-13 | |||||
タイトル | ||||||
タイトル | Tyrphostin AG 1478 Accelerates Hydrogen Peroxide-Induced Apoptosis in A431 Cells | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | EGFR | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | H_20_2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Tyrphostin AG1478 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | apoptosis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Tsukada, Toshiaki
× Tsukada, Toshiaki× Ida, Hiroaki× Kawakami, Atsushi× Eguchi, Katsumi× Harris, Raymond C. |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Oxidative stress is a potent inducer of apoptosis and activates protein tyrosine kinases and cytokine receptors, such as the epidermal growth factor receptor (EGFR). Previous studies suggest that cytokine receptors are potential effectors for anti-apoptotic signals, but it has not previously been determined whether cytokine receptors regulate down-stream protein kinases. To investigate the role of EGFR on oxidative stress-induced apoptosis and its downstream protein kinases, we blocked EGFR activation with Tyrphostin AG1478, a highly selective EGFR inhibitor. We determined that Tyrphostin AG1478 accelerated hydrogen peroxide-induced apoptosis in A431 cells, with activation of caspases 3 and 9, and decreased mitochondrial membrane potential. Hydrogen peroxide induced-activation of EGFR, Akt/PKB, MAPK, and Bad (both Ser-112 and Ser-136 residues) were inhibited by Tyrphostin AG1478. These results suggest that early upstream signaling events, such as EGFR activation, exert anti-apoptotic effects by regulating MAPK, Akt/PKB, and phosphorylation of Bad. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 48, 号 3-4, p. 117-123, 発行日 2003-12-24 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00117-P00123 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 2003, 48(3-4), p.117-123 |