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This has long been interpreted as an excessive energy deposition over the necessary energy required to produce a biologically effective event. Here, we present an alternative interpretation. Cell traversed by a charged particle has certain probability to receive lethal damage leading to direct death. Such events may increase with an increase of LET and the number of charged particles traversing the cell. Assuming that the lethal damage is distributed according to a Poisson distribution, the probability that a cell has no such damage is expressed by e^\u003ccLx\u003e , where c is a constant, L is LET, and x is the number of charged particles traversing the cell. From these assumptions, the frequency of chromosome aberration in surviving cells can be described by Y = αSD + βS^2 D^2 with the empirical relation Y = αD + βD^2 in the low LET region, where S = e^\u003c-cL\u003e , αis a value proportional to LET, βis a constant, and D is the absorbed dose. 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Generalized Concept of the LET-RBE Relationship of Radiation-induced Chromosome Aberration and Cell Death
http://hdl.handle.net/10069/16840
http://hdl.handle.net/10069/16840616fb42b-ac9c-4c9c-8082-bd492d389a5b
名前 / ファイル | ライセンス | アクション |
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jRR40_1_59.pdf (191.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-04-30 | |||||
タイトル | ||||||
タイトル | Generalized Concept of the LET-RBE Relationship of Radiation-induced Chromosome Aberration and Cell Death | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Radiation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | LET | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | RBE | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Chromosome aberration | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cell killing | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Takatsuji, Toshihiro
× Takatsuji, Toshihiro× Yoshikawa, Isao× Sasaki, Masao S. |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The frequency of chromosome aberrations per traversal of a nucleus by a charged particle at the low dose limit increases proportionally to the square of the linear energy transfer (LET), peaks at about 100 keV/μm and then decreases with further increase of LET. This has long been interpreted as an excessive energy deposition over the necessary energy required to produce a biologically effective event. Here, we present an alternative interpretation. Cell traversed by a charged particle has certain probability to receive lethal damage leading to direct death. Such events may increase with an increase of LET and the number of charged particles traversing the cell. Assuming that the lethal damage is distributed according to a Poisson distribution, the probability that a cell has no such damage is expressed by e^<cLx> , where c is a constant, L is LET, and x is the number of charged particles traversing the cell. From these assumptions, the frequency of chromosome aberration in surviving cells can be described by Y = αSD + βS^2 D^2 with the empirical relation Y = αD + βD^2 in the low LET region, where S = e^<-cL> , αis a value proportional to LET, βis a constant, and D is the absorbed dose. This model readily explains the empirically established relationship between LET and relative biological effectiveness (RBE). The model can also be applied to clonogenic survival. If cells can survive and they have neither unstable chromosome aberrations nor other lethal damage, the LET-RBE relationship for clonogenic survival forms a humped curve. The relationship between LET and inactivation cross-section becomes proportional to the square of LET in the low LET region when the frequency of a directly lethal events is sufficiently smaller than unity, and the inactivation cross-section saturates to the cell nucleus cross-sectional area with an increase in LET in the high LET region. | |||||
書誌情報 |
Journal of radiation research 巻 40, 号 1, p. 59-69, 発行日 1999-03 |
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出版者 | ||||||
出版者 | 日本放射線影響学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 04493060 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00705792 | |||||
権利 | ||||||
権利情報 | 日本放射線影響学会 | |||||
権利 | ||||||
権利情報 | 本文データは学協会の許諾に基づきCiNiiから複製したものである | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of radiation research. 1999, 40(1), p.59-69 |