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However, it is unclear whether the IK assay is utilized during the acute postoperative periods following living donor liver transplantation (LDLT). Methods: The IK values of 43 LDLT recipients were measured during the month following LDLT to evaluate the relationship between the measured IK values and infectious events. Results: The IK values after LDLT were significantly increased compared with the IK values before LDLT (P \u003c 0.01). During the month following transplantation, the rate of bacterial infection in the recipients with IK values of more than 225 ng/mL was significantly lower than that in the recipients with IK values of 225 ng/mL or less (42.1% vs 91.7%, respectively; P \u003c 0.01). The rate of severe infections among the recipients who maintained IK values of more than 150 ng/mL was significantly lower than that among the recipients with IK values of 150 ng/mL or less during the month following transplantation (3.7% vs 56.3%, respectively; P \u003c 0.01). 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Relationship between immune function recovery and infectious complications in patients following living donor liver transplantation
http://hdl.handle.net/10069/37307
http://hdl.handle.net/10069/37307446a1bca-88cb-4baf-9a73-0c251ce61b6d
名前 / ファイル | ライセンス | アクション |
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HepRes46_908.pdf (1.3 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-09-01 | |||||
タイトル | ||||||
タイトル | Relationship between immune function recovery and infectious complications in patients following living donor liver transplantation | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | bacterial and fungal infection | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ImmuKnow | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | immunosuppression | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | living donor liver transplantation | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kobayashi, Shinichiro
× Kobayashi, Shinichiro× Soyama, Akihiko× Takatsuki, Mitsuhisa× Hidaka, Masaaki× Adachi, Tomohiko× Kitasato, Amane× Kinoshita, Ayaka× Hara, Takanobu× Kanetaka, Kengo× Fujita, Fumihiko× Kuroki, Tamotsu× Eguchi, Susumu |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Aim: The ImmuKnow (IK) assay enables the evaluation of peripheral blood CD4+ adenosine triphosphate activity to facilitate an objective assessment of the cellular immune function in immunosuppressed patients. However, it is unclear whether the IK assay is utilized during the acute postoperative periods following living donor liver transplantation (LDLT). Methods: The IK values of 43 LDLT recipients were measured during the month following LDLT to evaluate the relationship between the measured IK values and infectious events. Results: The IK values after LDLT were significantly increased compared with the IK values before LDLT (P < 0.01). During the month following transplantation, the rate of bacterial infection in the recipients with IK values of more than 225 ng/mL was significantly lower than that in the recipients with IK values of 225 ng/mL or less (42.1% vs 91.7%, respectively; P < 0.01). The rate of severe infections among the recipients who maintained IK values of more than 150 ng/mL was significantly lower than that among the recipients with IK values of 150 ng/mL or less during the month following transplantation (3.7% vs 56.3%, respectively; P < 0.01). Conclusion: The immune system of LDLT recipients dramatically improved following transplantation. The IK values of LDLT recipients were associated with the incidence of infectious events during the perioperative period after LDLT. Monitoring IK values was useful during both the acute and long-term postoperative periods. | |||||
書誌情報 |
Hepatology Research 巻 46, 号 9, p. 908-915, 発行日 2016-08 |
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出版者 | ||||||
出版者 | 日本肝臓学会 | |||||
出版者別言語 | ||||||
Japan Society of Hepatology | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13866346 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1111/hepr.12635 | |||||
権利 | ||||||
権利情報 | c 2015 The Japan Society of Hepatology | |||||
権利 | ||||||
権利情報 | This is the peer reviewed version of the following article: Hepatology Research, 46(9), pp.908-915; 2016, which has been published in final form at http://dx.doi.org/10.1111/hepr.12635 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Hepatology Research, 46(9), pp.908-915; 2016 |