A total of twenty-five 40-day-old, male, Japanese quails were fed with either basal diet, a diet containing 15% butter fat and 2% cholesterol, or a diet containing 15% fish oil and 2% cholesterol for 3 months. The birds which were fed with the diet containing lard and cholesterol showed marked hypercholesterolemia and severe lipid-rich aortic lesions. In accordance to serum cholesterol level, the lard fed group had numerous fibroblasts with or without lipid droplets in the thickened intima of the ascending aorta. The birds fed with the fish oil and cholesterol had no significant increase in their serum cholesterol level or lipid-rich aortic lesions. These data clearly indicate that fish oil is less atherogenic than lard.
Effects of dietary lard and fish oil on the serum lipid level and aortic tissue : a comparison in quail animal model
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