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Class II MHC Antigen Expression in Bronchial Lavage Cells in a Canine Lung Allograft Model using FK506 Immunosuppression
http://hdl.handle.net/10069/15954
http://hdl.handle.net/10069/1595418ce1c83-db34-4230-aa29-a4c1b812a68e
名前 / ファイル | ライセンス | アクション |
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acta38_02_51_t.pdf (733.6 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-03-13 | |||||
タイトル | ||||||
タイトル | Class II MHC Antigen Expression in Bronchial Lavage Cells in a Canine Lung Allograft Model using FK506 Immunosuppression | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | lung transplantation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | rejection | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | bronchoalveolar lavage | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | class II MHC antigen | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Kawahara, Katsunobu
× Kawahara, Katsunobu× Akamine, Shinji× Takahashi, Takao× Nakamura, Akihiro× Muraoka, Masashi× Tagawa, Tsutomu× Yamamoto, Satoshi× Tomita, Masao |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Footnotes: Katsunobu Kawahara, MD., The First Department of Surgery, Nagasaki University School Medicine, Sakamoto-machi 7-1 #852, Nagasaki, Japan, TEL 0958-47-2111, FAX 0958-47-5034 Abbreviations: MHC: Major histocompatibility antigens, CsA: Cyclosporine A, BAL: Bronchoalveolar lavage, APC: Antigen presenting cell To assess the effect of FK506 on class II MHC antigen expression on lymphocytes recovered from bronchoalveolar lavage (BAL) in dogs following left lung allotransplantation, flow cytometric anlysis with OKIa-1 monoclonal antibody was performed. Dogs were divided into two groups: Group 1 (n = 6), control group (dogs without surgery); Group 2 (n = 23), dogs recieving left lung allotransplantation and immunosuppression using FK506 (0.1mg/kg/day intramuscularly). No significant difference existed in the percentage of OKIa-1 positive lymphocytes recovered from control animals (31.2 ± 11.2%) vs. normal allografts in Group 2 (34.8 ± 8.5%, n = 16). With rejection, however, the percentage of OKIa-1 positive lymphocytes increases significantly in Group 2: 56.2 ± 10.3% in mild rejection (n = 6) and 91.4 ± 4.3% in moderate or severe rejection (n = 4) (p < 0.01). Chest radiographs appeared normal in allografted lungs with histologically mild rejection. The percentage of the OKIa-1 positive lymphocytes in BAL did not significantly change during the first, second, or third week following transplantation, ((32.2 ± 6.4 (n = 5), 36.4 ± 4.2 (n = 4), and 35.8 ± 12.3 (n = 7), respectively)) in the allografted lungs without rejection. FK506 does not affect the class II MHC antigen expression of lymphocytes recovered from BAL in canine allografted lungs without rejection. Furthermore, this compound does not change in class II antigen expression seen with allograft rejection. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 38, 号 2-4, p. 273-278, 発行日 1993-12-25 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00273-P00278 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 1993, 38(2-4), p.273-278 |