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Molecular Epidemiology of Rotaviruses
http://hdl.handle.net/10069/9269
http://hdl.handle.net/10069/92690dc2c97f-aabd-452a-ad1b-a7a5b9b7453c
名前 / ファイル | ライセンス | アクション |
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acta49_03_67.pdf (1.2 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2007-11-02 | |||||
タイトル | ||||||
タイトル | Molecular Epidemiology of Rotaviruses | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Rotavirus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Genome | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Electropherotype | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Strain | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Reassortant | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Nakagomi, Osamu
× Nakagomi, Osamu |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Molecular epidemiology of rotaviruses emerged a little over 25 years ago as a fascinating branch of science that utilized then cutting-edge technology of RNA polyacrylamide gel electrophoresis. Molecular epidemiology, as I have observed it closely almost since its dawn, is an ever-evolving discipline which has incorporated the advances of the related sciences including molecular evolutionary biology and ecology, while it is firmly and deeply rooted in the edifice of epidemiology of infectious diseases. Rotavirus is a non-enveloped virus possessing 11 segments of double-stranded RNA as the genome and belongs to the Reoviridae family. The consequences of rotavirus infections in terms of mortality are different depending on whether children live in the developing countries or they live in the developed countries, and this difference comes mostly from the availability of proper medical intervention. A second generation rotavirus vaccine has just been licensed in Mexico and will hopefully be used widely among countries where the burden of the disease is the highest. One potential threat to the existing and future rotavirus vaccines is the extreme diversity of strains circulating among children across the world, and it is the key to understand how rotaviruses maintain themselves in nature. Molecular epidemiology of rotaviruses helps address such questions and has demystified the way in which they evolve including interspecies transmission of rotaviruses. A few examples are provided from the work that my colleagues and I did over the course of my career in an attempt to give a feel of molecular epidemiology of rotaviruses. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 49, 号 3, p. 67-73, 発行日 2004-09 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関係URI | ||||||
関連名称 | http://joi.jlc.jst.go.jp/JST.JSTAGE/amn/49.67 | |||||
sortkey | ||||||
P00067-P00073 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 2004, 49(3), p.67-73 |