WEKO3
アイテム
{"_buckets": {"deposit": "dd5204e3-bbd8-4871-9f53-e38cef6dfa82"}, "_deposit": {"created_by": 2, "id": "22599", "owners": [2], "pid": {"revision_id": 0, "type": "depid", "value": "22599"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:00022599", "sets": ["1610"]}, "author_link": ["96148", "96147", "96144", "96143", "96142", "96150", "96145", "96146", "96149"], "item_3_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2005-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "43", "bibliographicPageStart": "39", "bibliographicVolumeNumber": "50", "bibliographic_titles": [{"bibliographic_title": "Acta medica Nagasakiensia"}]}]}, "item_3_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "In this report, we describe a case of recurrent desmoid tumor that was characterized by a novel APC gene mutation and osteopontin (OPN) expression. A 20-year-old female patient with adenomatous polyposis underwent a right colectomy at 13 years of age. Five years later, she developed an abdominal desmoid tumor that was resected. After 2 more years, a recurrent desmoid tumor was found in the same region. This tumor grew rapidly and quickly became massive. The doubling time was estimated to be 122 days, based on the computed tomography findings. When we analyzed the APC gene in the recurrent desmoid tumor, we found a novel frame-shift mutation at codon 1564. This frame-shift mutation changed TTA to TAG, which is a stop codon. Northern blot analysis and immunohistochemical analysis for OPN, a GRGDS (glycine-arginine-glycine-aspartic acid-serine)- containing adhesive molecule, revealed abundant amounts of OPN mRNA and protein expression in this desmoid tumor. We postulated that the truncated APC protein and OPN expression might be involved in the invasive nature of this recurrent desmoid tumor. A primary cell culture derived from the desmoid tumor was assessed for chemosensitivity to 5-fluorouracil, cisplatin, doxorubicin, colchicine, docetaxel, and anti-OPN antibody. Docetaxel was found to have the strongest inhibitory effect on cell growth. As a result, docetaxel was administered to this patient (60 mg/m2/month) for 3 cycles. Over the next 2 years, no detectable recurrences occurred. Thus, docetaxel was clinically effective for the treatment of a recurrent desmoid tumor.", "subitem_description_type": "Abstract"}]}, "item_3_description_64": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "Acta medica Nagasakiensia. 2005, 50(1), p.39-43", "subitem_description_type": "Other"}]}, "item_3_relation_42": {"attribute_name": "関係URI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "http://joi.jlc.jst.go.jp/JST.JSTAGE/amn/50.39"}]}]}, "item_3_source_id_10": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508430", "subitem_source_identifier_type": "NCID"}]}, "item_3_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00016055", "subitem_source_identifier_type": "ISSN"}]}, "item_3_text_62": {"attribute_name": "sortkey", "attribute_value_mlt": [{"subitem_text_value": "P00039-P00043"}]}, "item_3_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Hayashida, Naomi"}], "nameIdentifiers": [{"nameIdentifier": "96142", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Maeda, Shigeto"}], "nameIdentifiers": [{"nameIdentifier": "96143", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tajima, Yoshitsugu"}], "nameIdentifiers": [{"nameIdentifier": "96144", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okudaira, Sadanori"}], "nameIdentifiers": [{"nameIdentifier": "96145", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsuzaki, Sumihiro"}], "nameIdentifiers": [{"nameIdentifier": "96146", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tanaka, Katsumi"}], "nameIdentifiers": [{"nameIdentifier": "96147", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hayashi, Tomayoshi"}], "nameIdentifiers": [{"nameIdentifier": "96148", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Furui, Jun-Ichirou"}], "nameIdentifiers": [{"nameIdentifier": "96149", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kanematsu, Takashi"}], "nameIdentifiers": [{"nameIdentifier": "96150", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "acta50_01_39.pdf", "filesize": [{"value": "233.2 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 233200.0, "url": {"label": "acta50_01_39.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/22599/files/acta50_01_39.pdf"}, "version_id": "c232c40c-8b12-4a14-ac68-55bbce3dad40"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Desmoidtumor", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Chemosensitivity", "subitem_subject_scheme": "Other"}, {"subitem_subject": "APCgene", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Chemosensitivity of a Recurrent Desmoid Tumor with Increased Osteopontin Expression and a Novel Frame-Shift Mutation at Codon 1564 of the APC Gene", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Chemosensitivity of a Recurrent Desmoid Tumor with Increased Osteopontin Expression and a Novel Frame-Shift Mutation at Codon 1564 of the APC Gene"}]}, "item_type_id": "3", "owner": "2", "path": ["1610"], "permalink_uri": "http://hdl.handle.net/10069/9327", "pubdate": {"attribute_name": "公開日", "attribute_value": "2007-11-02"}, "publish_date": "2007-11-02", "publish_status": "0", "recid": "22599", "relation": {}, "relation_version_is_last": true, "title": ["Chemosensitivity of a Recurrent Desmoid Tumor with Increased Osteopontin Expression and a Novel Frame-Shift Mutation at Codon 1564 of the APC Gene"], "weko_shared_id": -1}
Chemosensitivity of a Recurrent Desmoid Tumor with Increased Osteopontin Expression and a Novel Frame-Shift Mutation at Codon 1564 of the APC Gene
http://hdl.handle.net/10069/9327
http://hdl.handle.net/10069/9327b60f86fd-422f-4c3a-89a5-ed19d5a63580
名前 / ファイル | ライセンス | アクション |
---|---|---|
acta50_01_39.pdf (233.2 kB)
|
|
Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2007-11-02 | |||||
タイトル | ||||||
タイトル | Chemosensitivity of a Recurrent Desmoid Tumor with Increased Osteopontin Expression and a Novel Frame-Shift Mutation at Codon 1564 of the APC Gene | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Desmoidtumor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Chemosensitivity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | APCgene | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Hayashida, Naomi
× Hayashida, Naomi× Maeda, Shigeto× Tajima, Yoshitsugu× Okudaira, Sadanori× Matsuzaki, Sumihiro× Tanaka, Katsumi× Hayashi, Tomayoshi× Furui, Jun-Ichirou× Kanematsu, Takashi |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In this report, we describe a case of recurrent desmoid tumor that was characterized by a novel APC gene mutation and osteopontin (OPN) expression. A 20-year-old female patient with adenomatous polyposis underwent a right colectomy at 13 years of age. Five years later, she developed an abdominal desmoid tumor that was resected. After 2 more years, a recurrent desmoid tumor was found in the same region. This tumor grew rapidly and quickly became massive. The doubling time was estimated to be 122 days, based on the computed tomography findings. When we analyzed the APC gene in the recurrent desmoid tumor, we found a novel frame-shift mutation at codon 1564. This frame-shift mutation changed TTA to TAG, which is a stop codon. Northern blot analysis and immunohistochemical analysis for OPN, a GRGDS (glycine-arginine-glycine-aspartic acid-serine)- containing adhesive molecule, revealed abundant amounts of OPN mRNA and protein expression in this desmoid tumor. We postulated that the truncated APC protein and OPN expression might be involved in the invasive nature of this recurrent desmoid tumor. A primary cell culture derived from the desmoid tumor was assessed for chemosensitivity to 5-fluorouracil, cisplatin, doxorubicin, colchicine, docetaxel, and anti-OPN antibody. Docetaxel was found to have the strongest inhibitory effect on cell growth. As a result, docetaxel was administered to this patient (60 mg/m2/month) for 3 cycles. Over the next 2 years, no detectable recurrences occurred. Thus, docetaxel was clinically effective for the treatment of a recurrent desmoid tumor. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 50, 号 1, p. 39-43, 発行日 2005-03 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関係URI | ||||||
関連名称 | http://joi.jlc.jst.go.jp/JST.JSTAGE/amn/50.39 | |||||
sortkey | ||||||
P00039-P00043 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 2005, 50(1), p.39-43 |