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Effect of application volume and area on the absorption of phenol red as a model drug from the liver surface in rats
http://hdl.handle.net/10069/6674
http://hdl.handle.net/10069/66747fc2ff5d-95ec-49ce-b87e-a6a45256c905
名前 / ファイル | ライセンス | アクション |
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JPP49_976.pdf (186.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-02-21 | |||||
タイトル | ||||||
タイトル | Effect of application volume and area on the absorption of phenol red as a model drug from the liver surface in rats | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Nishida, Koyo
× Nishida, Koyo× Sato, Norihito× Nakakoga, Yuki× Mukai, Takahiro× Sasaki, Hitoshi× Nakamura, Junzo |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We examined the importance of application volume and area in the absorption of phenol red as a model drug from the rat liver surface, for pharmaceutical formulation concerning administration form. When 1 mg of phenol red was applied to the rat liver surface in-vivo using a cylindrical glass cell (i.d. 9 mm) in three volumes (0.1, 0.2 or 0.334 mL), the shape of the plasma concentration pattern differed greatly, particularly the maximum concentration. These patterns were well fitted by a two-compartment model with first-order absorption, and the obtained absorption rate constant Ka decreased inversely according to the application volume. The absorption ratio and biliary recovery of phenol red at 6 h was increased with glass cell area (i.d. 6, 9 or 14 mm; area 0.28, 0.64 or 1.54 cm2). Furthermore, the permeability coefficient Papp derived from Ka did not depend on application area, indicating no difference in absorption characteristics of liver surface. This also implies transport of a drug by a passive diffusion from the liver surface. After intraperitoneal administration to the rat liver surface for clinical application, increase in application volume resulted in the delayed disappearance of phenol red from plasma. However, the difference was not as marked as that using a glass cell. The assumption that the effective area relating to the absorption changed with the application volume enabled us to estimate Papp. Consequently, we speculate absorbability can be estimated precisely by considering application volume and area. | |||||
書誌情報 |
Journal of Pharmacy and Pharmacology 巻 49, 号 10, p. 976-980, 発行日 1997-10 |
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出版者 | ||||||
出版者 | Pharmaceutical Press | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00223573 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00704643 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 9364405 | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Pharmacy and Pharmacology, 49 (10), 976-980, 1997 |