To investigate whether or not protoporphyria can be induced in hairless mice, feed containing 0.5% griseofulvin (GF) was given to hairless Hos^<[○!R]> HR/De strain mice for two to four months. Administration of GF caused protoporphyria in the hairless mice, that is, protoporphyrin levels in the erythrocytes and the liver were extremely elevated. Acute skin changes such as erythema, edema, blister and crust formation were produced by exposing the hairless mice with protoporphyria to 400 nm of light using the metal halide lamp. From these results, we confirmed that hairless mice of HR/De strain can be utilized as a model for protoporphyria. These mice are useful for macroscopic and histopathological observations of skin changes and are also convenient for photosensitivity experiments.
雑誌名
熱帯医学 Tropical medicine
巻
30
号
3
ページ
219 - 224
発行年
1988-09-30
ISSN
03855643
書誌レコードID
AN00199644
出版者
長崎大学熱帯医学研究所
出版者別言語
Institute of Tropical Medicine, Nagasaki University
Induction of Experimental Protoporphyria in Hairless Mice by Griseofulvin
tm30_03_06_t.pdf
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