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Characterization of Proanthocyanidin Oligomers of Ephedra sinica
http://hdl.handle.net/10069/37779
http://hdl.handle.net/10069/37779f8d65857-990d-4316-92bd-ce4cf04841a6
名前 / ファイル | ライセンス | アクション |
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Mole22_1308.pdf (8.9 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-09-25 | |||||
タイトル | ||||||
タイトル | Characterization of Proanthocyanidin Oligomers of Ephedra sinica | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Ephedra sinica | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | proanthocyanidin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | oligomer | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | thiolysis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | phloroglucinolysis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | TDDFT | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ECD | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Orejola, Joanna
× Orejola, Joanna× Matsuo, Yosuke× Saito, Yoshinori× Tanaka, Takashi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Ephedra sinica, an important plant in Chinese traditional medicine, contains a complex mixture of proanthocyanidin oligomers as major constituents; however, only the minor components have been chemically characterized. In this study, oligomers with relatively large molecular weights, which form the main body of the proanthocyanidin fractions, were separated by adsorption and size-exclusion chromatography. Acid-catalyzed degradation in the presence of mercaptoethanol or phloroglucinol led to the isolation of 18 fragments, the structures of which were elucidated from their experimental and TDDFT-calculated ECD spectra. The results indicated that (?)-epigallocatechin was the main extension unit, while catechin, the A-type epigallocatechin?gallocatechin dimer, and the A-type epigallocatechin homodimer, were identified as the terminal units. Among the degradation products, thioethers of gallocatechin with 3,4-cis configurations, a B-type prodelphinidin dimer, a prodelphinidin trimer with both A- and B-type linkages, and a prodelphinidin dimer with an α-substituted A-type linkage were new compounds. In addition, a phloroglucinol adduct of an A-type prodelphinidin dimer, a doubly-linked phloroglucinol adduct of epigallocatechin, and a unique product with a flavan-3-ol skeleton generated by the rearrangement of the aromatic rings were also isolated. | |||||
書誌情報 |
Molecules 巻 22, 号 8, p. 1308, 発行日 2017-08-06 |
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出版者 | ||||||
出版者 | Multidisciplinary Digital Publishing Institute (MDPI) | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14203049 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3390/molecules22081308 | |||||
権利 | ||||||
権利情報 | c 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Molecules, 22(8), 1308; 2017 |