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Effect of probiotics on gut microbiome in patients with administration of surgical antibiotic prophylaxis: A randomized controlled study
http://hdl.handle.net/10069/00040545
http://hdl.handle.net/10069/00040545767c0361-b3f5-4ac5-b972-6ba7f84c5572
名前 / ファイル | ライセンス | アクション |
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JIC26_795.pdf (408.9 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-03-12 | |||||
タイトル | ||||||
タイトル | Effect of probiotics on gut microbiome in patients with administration of surgical antibiotic prophylaxis: A randomized controlled study | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Prophylaxis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Surgery | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Antibiotics | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Probiotics | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Microbiome | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kaku, Norihito
× Kaku, Norihito× Matsumoto, Nariyoshi× Sasaki, Daisuke× Tsuda, Keiichi× Kosai, Kosuke× Uno, Naoki× Morinaga, Yoshitomo× Tagami, Atsushi× Adachi, Shinji× Hasegawa, Hiroo× Osaki, Makoto× Yanagihara, Katsunori |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Surgical antibiotic prophylaxis (SAP) is recommended for the prevention of surgical site infections. However, there is a concern about adverse effects of SAP, such as antibiotic-associated diarrhea (AAD). To prevent AAD, administration of probiotics has been investigated. Although recent advances in next-generation sequencing makes it possible to analyze the gut microbiome, the effect of probiotics on the gut microbiome in the patients with SAP remains unknown. To test a hypothesis that SAP influences the gut microbiome and probiotics prevent the influence, a randomized controlled study was conducted with patients who underwent spinal surgery at Nagasaki University Hospital. After obtaining informed consent, the patients were automatically classified into the non-probiotics group and the probiotics group. In the probiotics group, the patients took 1 g of Enterococcus faecium 129 BIO 3B-R, 3 times a day on postoperative days (PODs) 1–5. The feces of all patients were sampled before administration of SAP and on PODs 5 and 10. We compared alpha and beta diversity and differential abundance analysis of the gut microbiome before and after SAP. During the study period, a total of 33 patients were evaluated, comprising 17 patients in the non-probiotics group and 16 in the probiotics group. There was no significant difference between the groups regarding patient characteristics. In alpha and beta diversity, there were no significant differences among all combinations. In differential abundance analysis at operational taxonomic unit level, Streptococcus gallolyticus and Roseburia were significantly increased in the non-probiotics group and significantly decreased in the probiotics group. | |||||
書誌情報 |
Journal of Infection and Chemotherapy 巻 26, 号 8, p. 795-801, 発行日 2020-08 |
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出版者 | ||||||
出版者 | Elsevier Ltd | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1341321X | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.jiac.2020.03.008 | |||||
権利 | ||||||
権利情報 | © 2020 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Infection and Chemotherapy, 26(8), pp.795-801; 2020 |