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Recent advances in radiobiology with respect to pleiotropic aspects of tissue reaction
http://hdl.handle.net/10069/00040939
http://hdl.handle.net/10069/0004093978af2604-3ce4-4355-961b-65bb390981cf
名前 / ファイル | ライセンス | アクション |
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JRR62_i30.pdf (420.8 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-10-11 | |||||
タイトル | ||||||
タイトル | Recent advances in radiobiology with respect to pleiotropic aspects of tissue reaction | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | radiation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | tissue reaction | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cGAS-STING pathway | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cancer risk | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Suzuki, Keiji
× Suzuki, Keiji× Amrenova, Aidana× Mitsutake, Norisato |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | DNA double-strand breaks (DSBs) induced by ionizing radiation are the major cause of cell death, leading to tissue/organ injuries, which is a fundamental mechanism underlying the development of tissue reaction. Since unscheduled senescence, predominantly induced among epithelial tissues/organs, is one of the major modes of cell death in response to radiation exposure, its role in tissue reaction has been extensively studied, and it has become clear that senescence-mediated secretion of soluble factors is an indispensable component of the manifestation of tissue reaction. Recently, an unexpected link between cytoplasmic DSBs and innate immunity was discovered. The activation of cyclic GMP-AMP (cGAMP) synthase (cGAS) results in the stimulation of the cGAS–stimulator of interferon genes (STING) pathway, which has been shown to regulate the transactivation of a variety of secretory factors that are the same as those secreted from senescent cells. Furthermore, it has been proven that cGAS–STING pathway also mediates execution of the senescence process by itself. Hence, an autocrine/paracrine feedback loop has been discussed in previous literature in relation to its effect on the tissue microenvironment. As the tissue microenvironment plays a crucial role in cancer development, tissue reaction could be involved in the late health effects caused by radiation exposure. In this paper, the novel findings in radiation biology, which should provide a better understanding of the mechanisms underlying radiation-induced carcinogenesis, are overviewed. | |||||
書誌情報 |
Journal of Radiation Research 巻 62, 号 S1, p. i30-i35, 発行日 2021-05-05 |
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出版者 | ||||||
出版者 | Oxford University Press | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1349-9157 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1093/jrr/rraa086 | |||||
権利 | ||||||
権利情報 | © The Author(s) 2020. Published by Oxford University Press on behalf of The Japanese Radiation Research Society and Japanese Society for Radiation Oncology. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by- nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Radiation Research, 62(S1), pp. i30-i35; 2021 |