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Safety, efficacy, and analysis of key parameters after prophylactic administration of a sustained-release formulation of azithromycin in lung cancer surgery
http://hdl.handle.net/10069/00040989
http://hdl.handle.net/10069/00040989d68bddbb-d841-4b3c-8770-9d5bafe100ea
名前 / ファイル | ライセンス | アクション |
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APM10_5098.pdf (1.4 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-10-28 | |||||
タイトル | ||||||
タイトル | Safety, efficacy, and analysis of key parameters after prophylactic administration of a sustained-release formulation of azithromycin in lung cancer surgery | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Azithromycin (AZM) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | lung cancer surgery | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | prophylactic | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Taniguchi, Daisuke
× Taniguchi, Daisuke× Watanabe, Hironosuke× Morinaga, Yoshitomo× Sasaki, Daisuke× Matsuda, Junichi× Sato, Shuntaro× Kaku, Norihito× Miyazaki, Takuro× Matsumoto, Keitaro× Tsuchiya, Tomoshi× Sakaeda, Toshiyuki× Yanagihara, Katsunori× Nagayasu, Takeshi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: The current use of prophylactic antibiotics for lung cancer surgery requires modification in aging individuals with impaired lung function. A sustained-release formulation of azithromycin (AZM-SR) could help resolve some of these challenges with its sustained antibacterial and anti-inflammatory effects. The aim of this study was to examine the safety and efficacy of AZM-SR in lung cancer surgery as well as its anti-inflammatory effect. Methods: Fifty patients were included in the study, and AZM-SR was administered 1 day prior to the surgery. The clinical course, including postoperative complications, was monitored, and the concentration of AZM, bacterial culture, and inflammatory cytokine levels of resected lung specimens were evaluated. Results: No side effects related to AZM-SR were observed. Five cases of postoperative pneumonia (10%) were observed; technical issues were involved in 3 cases. All patients recovered well. Four cases showed positive bacterial culture upon lung tissue examination; however, this was not significantly correlated with postoperative complications. A negative correlation was observed between AZM concentration in lung tissue and interleukin-6 (IL-6) expression. Conclusions: Prophylactic utilization of AZM-SR in lung cancer surgery seems feasible. The anti-inflammatory effect of AZM might contribute additional beneficial effects in the perioperative management of lung cancer surgery. |
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書誌情報 |
Annals of Palliative Medicine 巻 10, 号 5, p. 5098-5107, 発行日 2021-04-08 |
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出版者 | ||||||
出版者 | AME Publishing Company | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 22245820 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.21037/apm-21-383 | |||||
権利 | ||||||
権利情報 | © 2021 Annals of Palliative Medicine. Published by AME Publishing Company. This is an open access article under the CC BY-NC-ND license(http://creativecommons.org/licenses/by-nc-nd/4.0/). | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Annals of Palliative Medicine, 10(5), pp. 5098-5107; 2021 |