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Performance of MALDI–TOF Mass Spectrometry in the Philippines
http://hdl.handle.net/10069/00041016
http://hdl.handle.net/10069/00041016a16c739c-75ad-4630-a3f7-239b7a5c4f82
名前 / ファイル | ライセンス | アクション |
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TMID6_112.pdf (480.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-11-11 | |||||
タイトル | ||||||
タイトル | Performance of MALDI–TOF Mass Spectrometry in the Philippines | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | MALDI–TOF MS | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | VITEK2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | biochemical methods | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | bacterial infection | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | LMIC | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Philippines | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Osa, Morichika
× Osa, Morichika× Belo, Maria Cecilia× Dela Merced, Zita× Villanueva, Annavi Marie G.× Mauhay, Jaira× Celis, Alyannah× Catli, Melissa× Suzuki, Shuichi× Ukawa, Tatsuya× Tamaki, Shingo× Dhoubhadel, Bhim Gopal× Ariyoshi, Koya× Telan, Elizabeth Freda O.× Umipig, Dorcas Valencia× Parry, Christopher M.× Saito, Nobu× Smith, Chris |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Identification of the causative pathogen in infectious diseases is important for surveillance and to guide treatment. In low- and middle-income countries (LMIC), conventional culture and identification methods, including biochemical methods, are reference-standard. Biochemical methods can lack sensitivity and specificity and have slow turnaround times, causing delays in definitive therapy. Matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI–TOF MS) is a rapid and accurate diagnostic method. Most studies comparing MALDI–TOF MS and biochemical methods are from high-income countries, with few reports from LMIC with tropical climates. The aim of this study was to assess the performance of MALDI–TOF MS compared to conventional methods in the Philippines. Clinical bacterial or fungal isolates were identified by both MALDI–TOF MS and automated (VITEK2) or manual biochemical methods in the San Lazaro Hospital, Metro Manila, the Philippines. The concordance between MALDI–TOF MS and automated (VITEK2) or manual biochemical methods was analyzed at the species and genus levels. In total, 3530 bacterial or fungal isolates were analyzed. The concordance rate between MALDI–TOF MS and biochemical methods was 96.2% at the species level and 99.9% at the genus level. Twenty-three isolates could not be identified by MALDI–TOF MS. In this setting, MALDI–TOF MS was accurate compared with biochemical methods, at both the genus and the species level. Additionally, MALDI–TOF MS improved the turnaround time for results. These advantages could lead to improved infection management and infection control in low- and middle-income countries, even though the initial cost is high. | |||||
書誌情報 |
Tropical Medicine and Infectious Disease 巻 6, 号 3, p. 112, 発行日 2021-06-26 |
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出版者 | ||||||
出版者 | MDPI | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2414-6366 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3390/tropicalmed6030112 | |||||
権利 | ||||||
権利情報 | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Tropical Medicine and Infectious Disease, 6(3), art. no. 112; 2021 |