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Association of Urinary Dickkopf-3 with Residual Renal Function Decline in Patients Undergoing Peritoneal Dialysis
http://hdl.handle.net/10069/00041022
http://hdl.handle.net/10069/00041022c0a90b08-1311-4b1b-bf98-917316d8599d
名前 / ファイル | ライセンス | アクション |
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Medicina57_631.pdf (508.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-11-12 | |||||
タイトル | ||||||
タイトル | Association of Urinary Dickkopf-3 with Residual Renal Function Decline in Patients Undergoing Peritoneal Dialysis | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | biomarker | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Dickkopf-3 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | peritoneal dialysis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | residual renal function | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Torigoe, Kenta
× Torigoe, Kenta× Muta, Kumiko× Tsuji, Kiyokazu× Yamashita, Ayuko× Torigoe, Miki× Abe, Shinichi× Ota, Yuki× Mukae, Hiroshi× Nishino, Tomoya |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background and Objectives: Urinary levels of dickkopf-3 (DKK-3) are associated with poor renal survival in patients with non-dialytic chronic kidney disease. However, it remains unknown whether urinary DKK-3 levels can predict residual renal function (RRF) decline in patients undergoing peritoneal dialysis (PD). Therefore, we investigated the correlation between urinary levels of DKK-3 and the subsequent rate of RRF decline in PD patients. Materials and Methods: This study included 36 PD patients who underwent multiple peritoneal equivalent tests during 2011–2021. The relationship between baseline clinical characteristics and the subsequent annual rate of Kt/V decline was investigated. Results: The annual rate of renal Kt/V decline was 0.29 (range: 0.05–0.48), which correlated with renal Kt/V (r = 0.55, p = 0.0005) and 24 h urinary DKK-3 excretion (r = 0.61, p < 0.0001). Similarly, 24 h urinary DKK-3 excretion (β = 0.44, p = 0.0015) and renal Kt/V (β = 0.38, p = 0.0059) were independently associated with the annual rate of renal Kt/V decline in multivariate analyses. Conclusions: Urinary DKK-3 assessment may help identify PD patients at a high risk of RRF decline. | |||||
書誌情報 |
Medicina 巻 57, 号 6, p. 631, 発行日 2021-06-18 |
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出版者 | ||||||
出版者 | MDPI | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1648-9144 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3390/medicina57060631 | |||||
権利 | ||||||
権利情報 | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Medicina (Lithuania), 57(6), art. no. 631;2021 |