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An Outbreak of Dengue Virus Serotype 2 Cosmopolitan Genotype in Nepal, 2017
http://hdl.handle.net/10069/00041033
http://hdl.handle.net/10069/00041033659dfb9b-2c76-4c81-ac2c-8059070792eb
名前 / ファイル | ライセンス | アクション |
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Viruses13_1444.pdf (1.6 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-11-16 | |||||
タイトル | ||||||
タイトル | An Outbreak of Dengue Virus Serotype 2 Cosmopolitan Genotype in Nepal, 2017 | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | dengue | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | dengue virus serotype 2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cosmopolitan genotype | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | whole genome sequencing | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Nepal | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ngwe Tun, Mya Myat
× Ngwe Tun, Mya Myat× Pandey, Kishor× Nabeshima, Takeshi× Kyaw, Aung Kyaw× Adhikari, Mandira× Raini, Sandra Kendra× Inoue, Shingo× Dumre, Shyam Prakash× Pandey, Basu Dev× Morita, Kouichi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Dengue virus (DENV) is one of the most prevalent neglected tropical diseases, with half of the world’s population at risk of infection. In Nepal, DENV was first reported in 2004, and its prevalence is increasing every year. The present study aimed to obtain and characterize the full-length genome sequence of DENV from the 2017 outbreak. Hospital-based surveillance was conducted in two provinces of Nepal during the outbreak. Acute-phase serum samples were collected from 141 clinically suspected dengue patients after the rainy season. By serological and molecular techniques, 37 (26.9%) and 49 (34.8%), respectively, were confirmed as dengue patients. The cosmopolitan genotype of DENV-2 was isolated from 27 laboratory-confirmed dengue patients. Genomic analysis showed many amino acid substitutions distributed mainly among the E, NS3, and NS5 genes. Phylogenetic analyses of the whole genome sequence revealed two clades (Asian and Indian) among DENV-2 isolates from Nepal. The DENV isolates from hilly and Terai areas were similar to Asian and Indian strains, respectively. Further genomic study on different DENV serotypes is warranted to understand DENV epidemics in Nepal, where there are limited scientific resources and infrastructure. | |||||
書誌情報 |
Viruses 巻 13, 号 8, p. 1444, 発行日 2021-07-24 |
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出版者 | ||||||
出版者 | MDPI | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1999-4915 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3390/v13081444 | |||||
権利 | ||||||
権利情報 | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Viruses, 13(8), art. no. 1444;2021 |