A 49-year-old Japanese man with a 2-month history of a fever, headache, and bilateral conjunctival hyperemia was admitted. His condition fulfilled the giant cell arteritis classification criteria (new headache, temporal artery tenderness, elevated ESR) and atypical Cogan’s syndrome (CS) with scleritis and sensorineural hearing loss (SNHL). The interleukin (IL)-6 serum level was extremely high. Two weeks after his insufficient response of SNHL and scleritis to oral prednisolone, we administered tocilizumab (TCZ); rapid improvements in scleritis and SNHL occurred. Early IL-6 target therapy can help prevent irreversible CS-induced sensory organ damage.
雑誌名
Internal medicine
巻
61
号
8
ページ
1265 - 1270
発行年
2022-04-15
出版者
Japanese Society of Internal Medicine
出版者別言語
日本内科学会
ISSN
13497235
DOI
10.2169/internalmedicine.7674-21
権利
Ⓒ 2022 The Japanese Society of Internal Medicine The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/ by-nc-nd/4.0/).
Atypical Cogan’s Syndrome Mimicking Giant Cell Arteritis Successfully Treated with Early Administration of Tocilizumab
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