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Serum Cytokines Usefulness for Understanding the Pathology in Allergic Bronchopulmonary Aspergillosis and Chronic Pulmonary Aspergillosis
http://hdl.handle.net/10069/00041543
http://hdl.handle.net/10069/000415431ccf9d25-e1fc-47ab-8461-1f22dc8f009c
名前 / ファイル | ライセンス | アクション |
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JF8_436.pdf (889.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-05-24 | |||||
タイトル | ||||||
タイトル | Serum Cytokines Usefulness for Understanding the Pathology in Allergic Bronchopulmonary Aspergillosis and Chronic Pulmonary Aspergillosis | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | allergic bronchopulmonary aspergillosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | chronic pulmonary aspergillosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | serum cytokine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IL-33 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IL-10/IL-5 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ito, Yuya
× Ito, Yuya× Takazono, Takahiro× Obase, Yasushi× Fukahori, Susumu× Ashizawa, Nobuyuki× Hirayama, Tatsuro× Tashiro, Masato× Yamamoto, Kazuko× Imamura, Yoshifumi× Hosogaya, Naoki× Fukushima, Chizu× Morinaga, Yoshitomo× Yanagihara, Katsunori× Izumikawa, Koichi× Mukae, Hiroshi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Allergic bronchopulmonary aspergillosis (ABPA) and chronic pulmonary aspergillosis (CPA) are important fungal infections caused by Aspergillus species. An overlap of ABPA and CPA has been reported; therefore, it is critical to determine whether the main pathology is ABPA or CPA and whether antifungals are required. In this study, we investigated whether the serum cytokine profile is useful for understanding the pathology and for differentiating between these diseases. We compared the various serum cytokine levels among healthy subjects and patients diagnosed with asthma, ABPA, or CPA at Nagasaki University Hospital between January 2003 and December 2018. In total, 14 healthy subjects, 19 patients with asthma, 11 with ABPA, and 10 with CPA were enrolled. Interleukin (IL) -5 levels were significantly higher in patients with ABPA than in those with CPA, and IL-33 and tumor necrosis factor (TNF) levels were significantly higher in patients with CPA than in those with asthma (p < 0.05, Dunn’s multiple comparison test). The sensitivity and specificity of the IL-10/IL-5 ratio (cutoff index 2.47) for diagnosing CPA were 70% and 100%, respectively. The serum cytokine profile is useful in understanding the pathology of ABPA and CPA, and the IL-10/IL-5 ratio may be a novel supplemental biomarker for indicating the pathology of CPA. | |||||
書誌情報 |
Journal of Fungi 巻 8, 号 5, p. 436, 発行日 2022-04-23 |
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出版者 | ||||||
出版者 | MDPI | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2309-608X | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3390/jof8050436 | |||||
権利 | ||||||
権利情報 | © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Fungi, 8(5), art. no. 436; 2022 |