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We aimed to demonstrate the relationship between lymphangiogenesis and liver regeneration after partial hepatectomy in the cholestatic liver. Methods and Results: C57BL/6 mice were subjected to 70% partial hepatectomy only (PH group, n?=?20) and 70% partial hepatectomy with temporary common bile duct (BD) obstruction by clipping (BD+PH group, n?=?20). Five mice per group were sacrificed at 1, 3, 5, and \n7 days after the procedure. The liver function was examined by blood tests, and the liver regeneration rate was assessed by body weight and liver weight. Immunohistochemical staining of lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1) showed liver lymphangiogenesis. The gene expression of lymphangiogenesis-associated factors (e.g., vascular endothelial growth factor receptor-3\n [VEGFR-3]) was examined by a real-time polymerase chain reaction. The liver function in the BD+PH group was worse than that in the PH group on postoperative day 1 (POD1) (aspartate aminotransferase: 6528?±?1641?U/L vs. 2741?±?368?U/L, p?\u003c?0.05,\n alanine aminotransferase: 4160?±?1255?U/L vs. 2315?±?357?U/L, total bilirubin: 1.36?±?1.16?mg/dL vs. 0.09?±?0.01?mg/dL), and the liver regeneration rate in the BD+PH group was worse on POD7 (4.57% vs. 5.91%, p?\u003c?0.05). The LYVE-1 expression in Glisson\u0027s capsule peaked on POD5 and POD7 in the PH and BD+PH groups, respectively. The peak gene expression of VEGFR-3 in the BD+PH group \nwas delayed in comparison with the PH group. Conclusions: Lymphangiogenesis after partial hepatectomy in the cholestatic liver\n was suggested to be delayed due to impaired liver regeneration and the late expression of VEGFR-3.", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "Lymphatic research and biology, 18(4), pp.322-328; 2020", "subitem_description_type": "Other"}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Mary Ann Liebert, Inc."}]}, "item_2_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1089/lrb.2019.0068", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "c 2020, Mary Ann Liebert, Inc. 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The Relationship Between Lymphangiogenesis and Liver Regeneration After Partial Hepatectomy in Cholestatic Mice
http://hdl.handle.net/10069/40254
http://hdl.handle.net/10069/402546a5a4d93-d737-49dd-949e-351780127cfc
名前 / ファイル | ライセンス | アクション |
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LRB18_322.pdf (569.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-12-16 | |||||
タイトル | ||||||
タイトル | The Relationship Between Lymphangiogenesis and Liver Regeneration After Partial Hepatectomy in Cholestatic Mice | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cholestatic liver | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | liver regeneration | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | lymphangiogenesis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | LYVE-1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | VEGFR-3 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Hamada, Takashi
× Hamada, Takashi× Hidaka, Masaaki× Takatsuki, Mitsuhisa× Sakai, Yusuke× Yu, Haung× Natsuda, Koji× Ono, Shinichiro× Adachi, Tomohiko× Soyama, Akihiko× Eguchi, Susumu |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: The mechanisms of lymphangiogenesis in the cholestatic liver after partial hepatectomy (PH) remain unclear. We aimed to demonstrate the relationship between lymphangiogenesis and liver regeneration after partial hepatectomy in the cholestatic liver. Methods and Results: C57BL/6 mice were subjected to 70% partial hepatectomy only (PH group, n?=?20) and 70% partial hepatectomy with temporary common bile duct (BD) obstruction by clipping (BD+PH group, n?=?20). Five mice per group were sacrificed at 1, 3, 5, and 7 days after the procedure. The liver function was examined by blood tests, and the liver regeneration rate was assessed by body weight and liver weight. Immunohistochemical staining of lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1) showed liver lymphangiogenesis. The gene expression of lymphangiogenesis-associated factors (e.g., vascular endothelial growth factor receptor-3 [VEGFR-3]) was examined by a real-time polymerase chain reaction. The liver function in the BD+PH group was worse than that in the PH group on postoperative day 1 (POD1) (aspartate aminotransferase: 6528?±?1641?U/L vs. 2741?±?368?U/L, p?<?0.05, alanine aminotransferase: 4160?±?1255?U/L vs. 2315?±?357?U/L, total bilirubin: 1.36?±?1.16?mg/dL vs. 0.09?±?0.01?mg/dL), and the liver regeneration rate in the BD+PH group was worse on POD7 (4.57% vs. 5.91%, p?<?0.05). The LYVE-1 expression in Glisson's capsule peaked on POD5 and POD7 in the PH and BD+PH groups, respectively. The peak gene expression of VEGFR-3 in the BD+PH group was delayed in comparison with the PH group. Conclusions: Lymphangiogenesis after partial hepatectomy in the cholestatic liver was suggested to be delayed due to impaired liver regeneration and the late expression of VEGFR-3. |
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書誌情報 |
Lymphatic Research and Biology 巻 18, 号 4, p. 322-328, 発行日 2020-08-17 |
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出版者 | ||||||
出版者 | Mary Ann Liebert, Inc. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 15396851 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 15578585 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1089/lrb.2019.0068 | |||||
権利 | ||||||
権利情報 | c 2020, Mary Ann Liebert, Inc. Final publication is available from Mary Ann Liebert, Inc., publishers http://dx.doi.org/10.1089/lrb.2019.0068. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Lymphatic research and biology, 18(4), pp.322-328; 2020 |