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Although the scale-up of GeneXpert testing \nis occurring, the benefits of universal Xpert-Mycobacterium tuberculosis/ rifampicin (MTB/RIF) testing in inpatients have not\n been documented. METHODS: Routine GeneXpert testing irrespective of priority criteria for testing was conducted within \na prospective cohort of all adults with known or presumptive TB admitted to a tertiary infectious diseases hospital in Manila. Study-specific TB diagnosis was decided upon bacteriological results, chest x-ray assessment, if already on anti-TB treatment (ATT) at admission and a cough duration of ?2 wk. RESULTS: Of submitted sputum samples, 87.1% (277/318) had valid acid-fast bacilli (AFB) microscopy and XpertR MTB/RIF results. XpertR MTB/RIF was positive in 97.7% (n = 87/89) of AFB-positive patients and 25.5% (n = 48/188) of AFB-negative patients. Bacteriological confirmation in smear negative cases not on ATT prior to admission was 25.2% (34/135). Rifampicin resistance was detected in 26/135 Xpert positive cases (19.3%), including nine \nwho might not otherwise have been detected, representing a 53% increase in yield. 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An observational report of universal GeneXpert testing of inpatients with diagnosed or presumptive TB in the Philippines
http://hdl.handle.net/10069/40255
http://hdl.handle.net/10069/40255bdaff7dc-a05e-4b97-822a-bcb6f154d533
名前 / ファイル | ライセンス | アクション |
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TRSTM114_682.pdf (538.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-09-10 | |||||
タイトル | ||||||
タイトル | An observational report of universal GeneXpert testing of inpatients with diagnosed or presumptive TB in the Philippines | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | adults | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | inpatients | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | TB diagnostics | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | XpertR MTB/RIF | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Thi, Aye Myat
× Thi, Aye Myat× Lee, Nathaniel× Parris, Victoria× Marin, Flora P× Roy, Lynsil× Calapis, Rugaiya W× Ariyoshi, Koya× Parry, Christopher M× Cox, Sharon E |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | BACKGROUND: The Philippines is a high TB and multidrug-resistant TB burden country. Although the scale-up of GeneXpert testing is occurring, the benefits of universal Xpert-Mycobacterium tuberculosis/ rifampicin (MTB/RIF) testing in inpatients have not been documented. METHODS: Routine GeneXpert testing irrespective of priority criteria for testing was conducted within a prospective cohort of all adults with known or presumptive TB admitted to a tertiary infectious diseases hospital in Manila. Study-specific TB diagnosis was decided upon bacteriological results, chest x-ray assessment, if already on anti-TB treatment (ATT) at admission and a cough duration of ?2 wk. RESULTS: Of submitted sputum samples, 87.1% (277/318) had valid acid-fast bacilli (AFB) microscopy and XpertR MTB/RIF results. XpertR MTB/RIF was positive in 97.7% (n = 87/89) of AFB-positive patients and 25.5% (n = 48/188) of AFB-negative patients. Bacteriological confirmation in smear negative cases not on ATT prior to admission was 25.2% (34/135). Rifampicin resistance was detected in 26/135 Xpert positive cases (19.3%), including nine who might not otherwise have been detected, representing a 53% increase in yield. CONCLUSION: Universal GeneXpert testing in this setting enhanced the yield of bacterial confirmation, revealing a high incidence of rifampicin resistance and suggesting a need for further investigations in Xpert-negative/smear-positive patients who may not have mycobacterial TB. |
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書誌情報 |
Transactions of The Royal Society of Tropical Medicine and Hygiene 巻 114, 号 9, p. 682-686, 発行日 2020-06-27 |
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出版者 | ||||||
出版者 | Oxford University Press | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00359203 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 18783503 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1093/trstmh/traa044 | |||||
権利 | ||||||
権利情報 | c The Author(s) 2020. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Transactions of the Royal Society of Tropical Medicine and Hygiene, 114(9), pp.682-686; 2020 |