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Therapeutic and Preventive Effects of Osteoclastogenesis Inhibitory Factor on Osteolysis, Proliferation of Mammary Tumor Cell and Induction of Cancer Stem Cells in the Bone Microenvironment
http://hdl.handle.net/10069/38243
http://hdl.handle.net/10069/38243e0a99eb9-a1e2-4961-b498-6474e627c2f1
名前 / ファイル | ライセンス | アクション |
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IJMS19_888.pdf (5.2 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-05-31 | |||||
タイトル | ||||||
タイトル | Therapeutic and Preventive Effects of Osteoclastogenesis Inhibitory Factor on Osteolysis, Proliferation of Mammary Tumor Cell and Induction of Cancer Stem Cells in the Bone Microenvironment | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | bone metastasis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | mammary tumor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | RANKL | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | bone microenvironment | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | osteoclastogenesis inhibitory factor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cancer stem cell | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Futakuchi, Mitsuru
× Futakuchi, Mitsuru× Nitanda, Takao× Ando, Saeko× Matsumoto, Harutoshi× Yoshimoto, Eri× Fukamachi, Katsumi× Suzui, Masumi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We examined the effects of recombinant human osteoclastogenesis inhibitory factor (hOCIF) on osteolysis, proliferation of mammary tumor cells, and induction of cancer stem cells (CSCs) in the tumor-bone and tumor-subcutaneous microenvironments (TB- and TS-microE). Methods: Mouse mammary tumor cells were transplanted onto the calvaria or into a subcutaneous lesion of female mice, creating a TB-microE and a TS-microE, and the mice were then treated with hOCIF. To investigate the preventive effects of hOCIF, mice were treated with hOCIF before tumor cell implantation onto the calvaria (Pre), after (Post), and both before and after (Whole). The number of CSCs and cytokine levels were evaluated by IHC and ELISA assay, respectively. Results: hOCIF suppressed osteolysis, and growth of mammary tumors in the TB-microE, but not in the TS-microE. In the Pre, Post, and Whole groups, hOCIF suppressed osteolysis, and cell proliferation. hOCIF increased mouse osteoprotegrin (mOPG) levels in vivo, which suppressed mammary tumor cell proliferation in vitro. These preventive effects were observed in the dose-dependent. hOCIF did not affect the induction of CSCs in either microenvironment. Conclusion: While receptor activator of NF-κB ligand (RANKL) targeting therapy may not affect the induction of CSCs, RANKL is a potential target for prevention as well as treatment of breast cancer bone metastasis. | |||||
書誌情報 |
International Journal of Molecular Sciences 巻 19, 号 3, p. 888, 発行日 2018-03 |
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出版者 | ||||||
出版者 | MDPI AG | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 16616596 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14220067 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3390/ijms19030888 | |||||
権利 | ||||||
権利情報 | c 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | International Journal of Molecular Sciences, 19(3), 888; 2018 |