WEKO3
アイテム
{"_buckets": {"deposit": "ed5575be-caa7-4a92-96f7-ea3449b6fe57"}, "_deposit": {"created_by": 2, "id": "3750", "owners": [2], "pid": {"revision_id": 0, "type": "depid", "value": "3750"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:00003750", "sets": ["26"]}, "author_link": ["15315", "15314", "15319", "15318", "15317", "15311", "15308", "15313", "15310", "15309", "15320", "15316", "15312", "15321", "15322"], "item_2_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2016-10", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "10", "bibliographicPageEnd": "1491", "bibliographicPageStart": "1484", "bibliographicVolumeNumber": "107", "bibliographic_titles": [{"bibliographic_title": "Cancer Science"}]}]}, "item_2_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "There is evidence that radiation exposure is a causative factor of myelodysplastic syndromes (MDS). However, little is known about whether radiation exposure is also a prognostic factor of MDS. We investigated the impact of radiation exposure on the prognosis of MDS in Nagasaki atomic bomb survivors using the International Prognostic Scoring System (IPSS) and the revised version (IPSS-R). Subjects were 140 patients with primary MDS diagnosed between 1985 and 2011 and evaluable for IPSS, IPSS-R, and exposure distance. Of those, 31 were exposed at \u003c1.5 km, 35 at 1.5?2.99 km, and 74 at ?3.0 km. By the end of March 2014, 47 patients (34%) progressed to overt leukemia and 106 (75.7%) died. By comparing with patients exposed at ?3.0 km, those exposed at \u003c1.5 km had significantly higher frequencies of abnormal chromosome (P = 0.02), intermediate/poor IPSS, and intermediate/poor/very poor IPSS-R cytogenetic category (P = 0.0001, and P \u003c 0.0001, respectively). As with de novo MDS, multivariate Cox regression analyses revealed that cytogenetic abnormalities, IPSS karyotype, and IPSS-R cytogenetics were significantly associated with poor survival, and cumulative incidence of leukemic transformation in MDS among atomic bomb survivors, but exposure distance was not associated with any poor outcomes. These suggest that exposure to the greater dose of atomic bomb radiation is associated with developing poor cytogenetic abnormalities in MDS, which might consequently lead to overt leukemia among atomic bomb survivors.", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "Cancer Science, 107(10), pp.1484-1491; 2016", "subitem_description_type": "Other"}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "日本癌学会"}]}, "item_2_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1111/cas.13025", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "c 2016 The Authors. Cancer Science published by John Wiley \u0026 Sons Australia, Ltd on behalf of Japanese Cancer Association. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is noncommercial and no modifications or adaptations are made."}]}, "item_2_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "13479032", "subitem_source_identifier_type": "ISSN"}]}, "item_2_text_62": {"attribute_name": "出版者別言語", "attribute_value_mlt": [{"subitem_text_value": "Japanese Cancer Association"}]}, "item_2_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Matsuo, Masatoshi"}], "nameIdentifiers": [{"nameIdentifier": "15308", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Iwanaga, Masako"}], "nameIdentifiers": [{"nameIdentifier": "15309", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kondo, Hisayoshi"}], "nameIdentifiers": [{"nameIdentifier": "15310", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Soda, Midori"}], "nameIdentifiers": [{"nameIdentifier": "15311", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Jo, Tatsuro"}], "nameIdentifiers": [{"nameIdentifier": "15312", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Horio, Kensuke"}], "nameIdentifiers": [{"nameIdentifier": "15313", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takasaki, Yumi"}], "nameIdentifiers": [{"nameIdentifier": "15314", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kawaguchi, Yasuhisa"}], "nameIdentifiers": [{"nameIdentifier": "15315", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tsushima, Hideki"}], "nameIdentifiers": [{"nameIdentifier": "15316", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Imaizumi, Yoshitaka"}], "nameIdentifiers": [{"nameIdentifier": "15317", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Imanishi, Daisuke"}], "nameIdentifiers": [{"nameIdentifier": "15318", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Taguchi, Jun"}], "nameIdentifiers": [{"nameIdentifier": "15319", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sawayama, Yasushi"}], "nameIdentifiers": [{"nameIdentifier": "15320", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hata, Tomoko"}], "nameIdentifiers": [{"nameIdentifier": "15321", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Miyazaki, Yasushi"}], "nameIdentifiers": [{"nameIdentifier": "15322", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-21"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "CanSci107_1484.pdf", "filesize": [{"value": "465.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 465000.0, "url": {"label": "CanSci107_1484.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/3750/files/CanSci107_1484.pdf"}, "version_id": "43be0f1b-3316-4961-adb0-8e9d541fb686"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Atomic bomb survivors", "subitem_subject_scheme": "Other"}, {"subitem_subject": "myelodysplastic syndromes", "subitem_subject_scheme": "Other"}, {"subitem_subject": "prognosis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "radiation exposure", "subitem_subject_scheme": "Other"}, {"subitem_subject": "therapy-related myeloid neoplasms", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Clinical features and prognosis of patients with myelodysplastic syndromes who were exposed to atomic bomb radiation in Nagasaki", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Clinical features and prognosis of patients with myelodysplastic syndromes who were exposed to atomic bomb radiation in Nagasaki"}]}, "item_type_id": "2", "owner": "2", "path": ["26"], "permalink_uri": "http://hdl.handle.net/10069/36934", "pubdate": {"attribute_name": "公開日", "attribute_value": "2016-11-24"}, "publish_date": "2016-11-24", "publish_status": "0", "recid": "3750", "relation": {}, "relation_version_is_last": true, "title": ["Clinical features and prognosis of patients with myelodysplastic syndromes who were exposed to atomic bomb radiation in Nagasaki"], "weko_shared_id": -1}
Clinical features and prognosis of patients with myelodysplastic syndromes who were exposed to atomic bomb radiation in Nagasaki
http://hdl.handle.net/10069/36934
http://hdl.handle.net/10069/36934af72c246-5781-47db-8dca-b94db833bca9
名前 / ファイル | ライセンス | アクション |
---|---|---|
CanSci107_1484.pdf (465.0 kB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2016-11-24 | |||||
タイトル | ||||||
タイトル | Clinical features and prognosis of patients with myelodysplastic syndromes who were exposed to atomic bomb radiation in Nagasaki | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Atomic bomb survivors | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | myelodysplastic syndromes | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | prognosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | radiation exposure | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | therapy-related myeloid neoplasms | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Matsuo, Masatoshi
× Matsuo, Masatoshi× Iwanaga, Masako× Kondo, Hisayoshi× Soda, Midori× Jo, Tatsuro× Horio, Kensuke× Takasaki, Yumi× Kawaguchi, Yasuhisa× Tsushima, Hideki× Imaizumi, Yoshitaka× Imanishi, Daisuke× Taguchi, Jun× Sawayama, Yasushi× Hata, Tomoko× Miyazaki, Yasushi |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | There is evidence that radiation exposure is a causative factor of myelodysplastic syndromes (MDS). However, little is known about whether radiation exposure is also a prognostic factor of MDS. We investigated the impact of radiation exposure on the prognosis of MDS in Nagasaki atomic bomb survivors using the International Prognostic Scoring System (IPSS) and the revised version (IPSS-R). Subjects were 140 patients with primary MDS diagnosed between 1985 and 2011 and evaluable for IPSS, IPSS-R, and exposure distance. Of those, 31 were exposed at <1.5 km, 35 at 1.5?2.99 km, and 74 at ?3.0 km. By the end of March 2014, 47 patients (34%) progressed to overt leukemia and 106 (75.7%) died. By comparing with patients exposed at ?3.0 km, those exposed at <1.5 km had significantly higher frequencies of abnormal chromosome (P = 0.02), intermediate/poor IPSS, and intermediate/poor/very poor IPSS-R cytogenetic category (P = 0.0001, and P < 0.0001, respectively). As with de novo MDS, multivariate Cox regression analyses revealed that cytogenetic abnormalities, IPSS karyotype, and IPSS-R cytogenetics were significantly associated with poor survival, and cumulative incidence of leukemic transformation in MDS among atomic bomb survivors, but exposure distance was not associated with any poor outcomes. These suggest that exposure to the greater dose of atomic bomb radiation is associated with developing poor cytogenetic abnormalities in MDS, which might consequently lead to overt leukemia among atomic bomb survivors. | |||||
書誌情報 |
Cancer Science 巻 107, 号 10, p. 1484-1491, 発行日 2016-10 |
|||||
出版者 | ||||||
出版者 | 日本癌学会 | |||||
出版者別言語 | ||||||
Japanese Cancer Association | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13479032 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1111/cas.13025 | |||||
権利 | ||||||
権利情報 | c 2016 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is noncommercial and no modifications or adaptations are made. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Cancer Science, 107(10), pp.1484-1491; 2016 |