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Calcium ions are involved in egress of Babesia bovis merozoites from bovine erythrocytes
http://hdl.handle.net/10069/35163
http://hdl.handle.net/10069/35163430998f1-8dc4-4907-a27d-495ae9279c01
名前 / ファイル | ライセンス | アクション |
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JVMS77_53.pdf (1.4 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2015-03-31 | |||||
タイトル | ||||||
タイトル | Calcium ions are involved in egress of Babesia bovis merozoites from bovine erythrocytes | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Babesia bovis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Calcium ionophore | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Calcium signalling | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Egress | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Mossaad, Ehab
× Mossaad, Ehab× Asada, Masahito× Nakatani, Daichi× Inoue, Noboru× Yokoyama, Naoaki× Kaneko, Osamu× Kawazu, Shin-ichiro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Bovine babesiosis is a livestock disease known to cause economic losses in endemic areas. The apicomplexan parasite Babesia bovis is able to invade and destroy the host's erythrocytes leading to the serious pathologies of the disease, such as anemia and hemoglobinuria. Understanding the egress mechanisms of this parasite is therefore a key step to develop new therapeutic strategies. In this study, the possible involvement of Ca2+ in the egress of B. bovis merozoites from infected erythrocytes was investigated. Egress was artificially induced in vitro using calcium ionophore A23187 and thapsigargin to increase Ca2+ concentration in the cytosol of the parasite cells. The increased intracellular Ca2+ concentration following these treatments was confirmed using live cell Ca2+ imaging with confocal laser scanning microscopy. Based on our findings, we suggest a Ca2+ signalling pathway in the egress of B. bovis merozoites. | |||||
書誌情報 |
Journal of Veterinary Medical Science 巻 77, 号 1, p. 53-58, 発行日 2015-02-17 |
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出版者 | ||||||
出版者 | 日本獣医学会 | |||||
出版者別言語 | ||||||
Japanese Society of Veterinary Science | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09167250 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13477439 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1292/jvms.14-0391 | |||||
権利 | ||||||
権利情報 | c 2015 by the Japanese Society of Veterinary Science | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Veterinary Medical Science, 77(1), pp.53-58; 2015 |