WEKO3
アイテム
{"_buckets": {"deposit": "1e1b4e0a-8098-489f-8a8c-90cb97be9e1a"}, "_deposit": {"created_by": 2, "id": "4146", "owners": [2], "pid": {"revision_id": 0, "type": "depid", "value": "4146"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:00004146", "sets": ["30"]}, "author_link": ["16503", "16509", "16511", "16512", "16515", "16507", "16505", "16514", "16516", "16510", "16504", "16517", "16506", "16513", "16508"], "item_2_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2015-04", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "120", "bibliographicPageStart": "114", "bibliographicVolumeNumber": "157", "bibliographic_titles": [{"bibliographic_title": "Clinical Immunology"}]}]}, "item_2_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Neuropsychiatric systemic lupus erythematosus (NPSLE) is a serious complication in SLE. Although the mechanism of NPSLE remains unclear, cytokines and chemokines are considered to be involved in their pathogenesis. Here we used Bio-Plex Pro assays to examine 27 types of cytokines and chemokines in the cerebrospinal fluid (CSF) of 32 NPSLE patients. We used the CSF of 20 patients with multiple sclerosis (MS) and 22 patients with neuromyelitis optica (NMO) as a disease control group. Fourteen of 27 cytokines/chemokines were significantly higher in the NPSLE patients compared to the MS/NMO patients. We could identify six \"minimum predictive markers\" by using a weighted-voting algorithm that could distinguish NPSLE from MS and NMO: interleukin (IL)-17, IL-2, interferon (IFN)-γ, IL-5, basic fibroblast growth factor (FGF)-basic and IL-15. The determination of various types of CSF cytokine profiles may contribute to the diagnosis of NPSLE and may help elucidate the mechanisms underlying this disease.", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "Clinical Immunology, 157(2), pp.114-120; 2015", "subitem_description_type": "Other"}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Academic Press Inc."}]}, "item_2_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1016/j.clim.2015.01.010", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "c 2015 Elsevier Inc."}, {"subitem_rights": "NOTICE: this is the author’s version of a work that was accepted for publication in Clinical Immunology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Clinical Immunology, 157, 2, (2015)"}]}, "item_2_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "15216616", "subitem_source_identifier_type": "ISSN"}]}, "item_2_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Ichinose, Kunihiro"}], "nameIdentifiers": [{"nameIdentifier": "16503", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Arima, Kazuhiko"}], "nameIdentifiers": [{"nameIdentifier": "16504", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ushigusa, Takeshi"}], "nameIdentifiers": [{"nameIdentifier": "16505", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nishino, Ayako"}], "nameIdentifiers": [{"nameIdentifier": "16506", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakashima, Yoshikazu"}], "nameIdentifiers": [{"nameIdentifier": "16507", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzuki, Takahisa"}], "nameIdentifiers": [{"nameIdentifier": "16508", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Horai, Yoshiro"}], "nameIdentifiers": [{"nameIdentifier": "16509", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakajima, Hideki"}], "nameIdentifiers": [{"nameIdentifier": "16510", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kawashiri, Shin-ya"}], "nameIdentifiers": [{"nameIdentifier": "16511", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Iwamoto, Naoki"}], "nameIdentifiers": [{"nameIdentifier": "16512", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tamai, Mami"}], "nameIdentifiers": [{"nameIdentifier": "16513", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakamura, Hideki"}], "nameIdentifiers": [{"nameIdentifier": "16514", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Origuchi, Tomoki"}], "nameIdentifiers": [{"nameIdentifier": "16515", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Motomura, Masakatsu"}], "nameIdentifiers": [{"nameIdentifier": "16516", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kawakami, Atsushi"}], "nameIdentifiers": [{"nameIdentifier": "16517", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-21"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "CliImm157_114.pdf", "filesize": [{"value": "517.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 517299.99999999994, "url": {"label": "CliImm157_114.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/4146/files/CliImm157_114.pdf"}, "version_id": "50d08a04-26cf-4e17-9906-6a7153e364c5"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Cerebrospinal fluid", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Cytokine profiles", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Neuropsychiatric systemic lupus erythematosus", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Weighted-voting algorithm", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Distinguishing the cerebrospinal fluid cytokine profile in neuropsychiatric systemic lupus erythematosus from other autoimmune neurological diseases", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Distinguishing the cerebrospinal fluid cytokine profile in neuropsychiatric systemic lupus erythematosus from other autoimmune neurological diseases"}]}, "item_type_id": "2", "owner": "2", "path": ["30"], "permalink_uri": "http://hdl.handle.net/10069/35260", "pubdate": {"attribute_name": "公開日", "attribute_value": "2015-04-30"}, "publish_date": "2015-04-30", "publish_status": "0", "recid": "4146", "relation": {}, "relation_version_is_last": true, "title": ["Distinguishing the cerebrospinal fluid cytokine profile in neuropsychiatric systemic lupus erythematosus from other autoimmune neurological diseases"], "weko_shared_id": -1}
Distinguishing the cerebrospinal fluid cytokine profile in neuropsychiatric systemic lupus erythematosus from other autoimmune neurological diseases
http://hdl.handle.net/10069/35260
http://hdl.handle.net/10069/35260ff057ffb-28f5-4070-917b-5313c178879f
名前 / ファイル | ライセンス | アクション |
---|---|---|
CliImm157_114.pdf (517.3 kB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2015-04-30 | |||||
タイトル | ||||||
タイトル | Distinguishing the cerebrospinal fluid cytokine profile in neuropsychiatric systemic lupus erythematosus from other autoimmune neurological diseases | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cerebrospinal fluid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cytokine profiles | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Neuropsychiatric systemic lupus erythematosus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Weighted-voting algorithm | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ichinose, Kunihiro
× Ichinose, Kunihiro× Arima, Kazuhiko× Ushigusa, Takeshi× Nishino, Ayako× Nakashima, Yoshikazu× Suzuki, Takahisa× Horai, Yoshiro× Nakajima, Hideki× Kawashiri, Shin-ya× Iwamoto, Naoki× Tamai, Mami× Nakamura, Hideki× Origuchi, Tomoki× Motomura, Masakatsu× Kawakami, Atsushi |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Neuropsychiatric systemic lupus erythematosus (NPSLE) is a serious complication in SLE. Although the mechanism of NPSLE remains unclear, cytokines and chemokines are considered to be involved in their pathogenesis. Here we used Bio-Plex Pro assays to examine 27 types of cytokines and chemokines in the cerebrospinal fluid (CSF) of 32 NPSLE patients. We used the CSF of 20 patients with multiple sclerosis (MS) and 22 patients with neuromyelitis optica (NMO) as a disease control group. Fourteen of 27 cytokines/chemokines were significantly higher in the NPSLE patients compared to the MS/NMO patients. We could identify six "minimum predictive markers" by using a weighted-voting algorithm that could distinguish NPSLE from MS and NMO: interleukin (IL)-17, IL-2, interferon (IFN)-γ, IL-5, basic fibroblast growth factor (FGF)-basic and IL-15. The determination of various types of CSF cytokine profiles may contribute to the diagnosis of NPSLE and may help elucidate the mechanisms underlying this disease. | |||||
書誌情報 |
Clinical Immunology 巻 157, 号 2, p. 114-120, 発行日 2015-04 |
|||||
出版者 | ||||||
出版者 | Academic Press Inc. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 15216616 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.clim.2015.01.010 | |||||
権利 | ||||||
権利情報 | c 2015 Elsevier Inc. | |||||
権利 | ||||||
権利情報 | NOTICE: this is the author’s version of a work that was accepted for publication in Clinical Immunology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Clinical Immunology, 157, 2, (2015) | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Clinical Immunology, 157(2), pp.114-120; 2015 |