WEKO3
アイテム
{"_buckets": {"deposit": "ad567a46-4665-400b-907f-400a99b0b3d7"}, "_deposit": {"created_by": 2, "id": "4179", "owners": [2], "pid": {"revision_id": 0, "type": "depid", "value": "4179"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:00004179", "sets": ["26"]}, "author_link": ["16764", "16761", "16762", "16765", "16767", "16766", "16763"], "item_2_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2015-02-24", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "7", "bibliographicPageEnd": "1148", "bibliographicPageStart": "1135", "bibliographicVolumeNumber": "10", "bibliographic_titles": [{"bibliographic_title": "Cell Reports"}]}]}, "item_2_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Satellite cells are resident skeletal muscle stem cells that supply myonuclei for homeostasis, hypertrophy, and repair in adult muscle. Scrib is one of the major cell-polarity proteins, acting as a potent tumor suppressor in epithelial cells. Here, we show that Scrib also controls satellite-cell-fate decisions in adult mice. Scrib is undetectable in quiescent cells but becomes expressed during activation. Scrib isasymmetrically distributed in dividing daughter cells, with robust accumulation in cells committed to myogenic differentiation. Low Scrib expression is associated with the proliferative state and preventing self-renewal, whereas high Scrib levels reduce satellite cell proliferation. Satellite-cell-specific knockout of Scrib in mice causes a drastic andinsurmountable defect in muscle regeneration. Thus, Scrib is a regulator of tissue stem cells, controlling population expansion and self-renewal with Scrib expression dynamics directing satellite cell fate.", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "Cell Reports, 10(7), pp.1135-1148; 2015", "subitem_description_type": "Other"}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Cell Press"}]}, "item_2_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1016/j.celrep.2015.01.045", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "c 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/)."}]}, "item_2_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "22111247", "subitem_source_identifier_type": "ISSN"}]}, "item_2_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Ono, Yusuke"}], "nameIdentifiers": [{"nameIdentifier": "16761", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Urata, Yoshishige"}], "nameIdentifiers": [{"nameIdentifier": "16762", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Goto, Shinji"}], "nameIdentifiers": [{"nameIdentifier": "16763", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakagawa, Shunsuke"}], "nameIdentifiers": [{"nameIdentifier": "16764", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Humbert, Patrick O."}], "nameIdentifiers": [{"nameIdentifier": "16765", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Li, Tao-Sheng"}], "nameIdentifiers": [{"nameIdentifier": "16766", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Zammit, Peter S."}], "nameIdentifiers": [{"nameIdentifier": "16767", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-21"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "CelRep10_1135.pdf", "filesize": [{"value": "4.9 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 4900000.0, "url": {"label": "CelRep10_1135.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/4179/files/CelRep10_1135.pdf"}, "version_id": "3962532d-e31a-45c6-8169-aea6476d92a8"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Muscle Stem Cell Fate Is Controlled by the Cell-Polarity Protein Scrib", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Muscle Stem Cell Fate Is Controlled by the Cell-Polarity Protein Scrib"}]}, "item_type_id": "2", "owner": "2", "path": ["26"], "permalink_uri": "http://hdl.handle.net/10069/35294", "pubdate": {"attribute_name": "公開日", "attribute_value": "2015-05-12"}, "publish_date": "2015-05-12", "publish_status": "0", "recid": "4179", "relation": {}, "relation_version_is_last": true, "title": ["Muscle Stem Cell Fate Is Controlled by the Cell-Polarity Protein Scrib"], "weko_shared_id": 2}
Muscle Stem Cell Fate Is Controlled by the Cell-Polarity Protein Scrib
http://hdl.handle.net/10069/35294
http://hdl.handle.net/10069/3529481eff060-b804-415e-a3ff-d182b4147202
名前 / ファイル | ライセンス | アクション |
---|---|---|
CelRep10_1135.pdf (4.9 MB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2015-05-12 | |||||
タイトル | ||||||
タイトル | Muscle Stem Cell Fate Is Controlled by the Cell-Polarity Protein Scrib | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ono, Yusuke
× Ono, Yusuke× Urata, Yoshishige× Goto, Shinji× Nakagawa, Shunsuke× Humbert, Patrick O.× Li, Tao-Sheng× Zammit, Peter S. |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Satellite cells are resident skeletal muscle stem cells that supply myonuclei for homeostasis, hypertrophy, and repair in adult muscle. Scrib is one of the major cell-polarity proteins, acting as a potent tumor suppressor in epithelial cells. Here, we show that Scrib also controls satellite-cell-fate decisions in adult mice. Scrib is undetectable in quiescent cells but becomes expressed during activation. Scrib isasymmetrically distributed in dividing daughter cells, with robust accumulation in cells committed to myogenic differentiation. Low Scrib expression is associated with the proliferative state and preventing self-renewal, whereas high Scrib levels reduce satellite cell proliferation. Satellite-cell-specific knockout of Scrib in mice causes a drastic andinsurmountable defect in muscle regeneration. Thus, Scrib is a regulator of tissue stem cells, controlling population expansion and self-renewal with Scrib expression dynamics directing satellite cell fate. | |||||
書誌情報 |
Cell Reports 巻 10, 号 7, p. 1135-1148, 発行日 2015-02-24 |
|||||
出版者 | ||||||
出版者 | Cell Press | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 22111247 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.celrep.2015.01.045 | |||||
権利 | ||||||
権利情報 | c 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/). | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Cell Reports, 10(7), pp.1135-1148; 2015 |