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Safety and efficacy of combination therapy with low-dose gemcitabine, paclitaxel, and sorafenib in patients with cisplatin-resistant urothelial cancer
http://hdl.handle.net/10069/35831
http://hdl.handle.net/10069/35831d48fa068-b76b-4a90-b79b-d0ad707bcdf1
名前 / ファイル | ライセンス | アクション |
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MedOnc32_235.pdf (398.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2015-09-11 | |||||
タイトル | ||||||
タイトル | Safety and efficacy of combination therapy with low-dose gemcitabine, paclitaxel, and sorafenib in patients with cisplatin-resistant urothelial cancer | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Gemcitabine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Paclitaxel | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Pain relief | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | QoL | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Sorafenib | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Urothelial cancer | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Miyata, Yasuyoshi
× Miyata, Yasuyoshi× Asai, Akihiro× Mitsunari, Kensuke× Matsuo, Tomohiro× Ohba, Kojiro× Sakai, Hideki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Various regimens including molecular targeted agents have been examined in patients with cisplatin (CDDP)-resistant urothelial cancer (UC). However, some studies have been stopped owing to the development of severe adverse events. The main aim of this study was to examine the anticancer effects, changes in the quality of life (QoL), and safety of combined therapy of low-dose gemcitabine, paclitaxel, and sorafenib (LD-GPS) in patients with CDDP-resistant UC. Twenty patients were treated with gemcitabine (700 mg/m2 on day 1), paclitaxel (70 mg/m2 on day 1), and sorafenib (400 mg/day on days 8?22). QoL and pain relief were evaluated using the short-form survey (SF)-36 for bodily pain and the visual analog scale (VAS). VAS scores were significantly decreased by both the second- and third-line therapies (P = 0.012 and 0.028, respectively). The bodily pain score from the SF-36 survey was also significantly (P = 0.012) decreased. Complete responses, partial responses, and stable disease were found in 0 (0.0 %), 1 (5.0 %), and 13 patients (65 %), respectively. The median (interquartile range) period of overall survival after starting of this therapy was 7 (5?11) months. Three patients (15.0 %) stopped therapy because of grade 3 fatigue and hand?foot reactions. LD-GPS therapy was well tolerated by patients with CDDP-resistant UC. QoL was maintained, and improvements in their pain levels were found after treatment; pain relief was detected after third-line therapy. We suggest that this treatment regimen is worthy of consideration as second- and third-line therapy for patients with CDDP-resistant UC. | |||||
書誌情報 |
Medical Oncology 巻 32, p. 235, 発行日 2015-10 |
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出版者 | ||||||
出版者 | Humana Press Inc. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13570560 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1559131X | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s12032-015-0683-y | |||||
権利 | ||||||
権利情報 | c The Author(s) 2015. This article is published with open access at Springerlink.com | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Medical Oncology, 32, 235; 2015 |