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β-Eudesmol induces the expression of apoptosis pathway proteins in cholangiocarcinoma cell lines
http://hdl.handle.net/10069/39659
http://hdl.handle.net/10069/39659451627b2-4f3a-4589-9ba1-06912479eaa7
名前 / ファイル | ライセンス | アクション |
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JRMS25_7.pdf (1.9 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-02-05 | |||||
タイトル | ||||||
タイトル | β-Eudesmol induces the expression of apoptosis pathway proteins in cholangiocarcinoma cell lines | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Apoptosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cholangiocarcinoma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | mode of action | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | molecular targets | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | β?eudesmol | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Karbwang, Juntra
× Karbwang, Juntra× Na-Bangchang, Kesara× Narahara, Chisato× Saeheng, Teerachat× Chaijaroenkul, Wanna× Dumre, ShyamPrakash |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: Cholangiocarcinoma (CCA) is a neglected disease prevalent in developing countries with high burden and mortality rate, and there is no effective treatment. We aimed to investigate β-eudesmol molecular target of action in human CCA cell lines using the selected key molecules of apoptotic pathways. Materials and Methods: Two CCA cell lines (HuH28 and HuCCT1) were assessed at different time points after β-eudesmol treatment for mRNA and protein expression profiles of caspase-3, -8, -9, p53, p21, Bcl-2, and Bax by real-time polymerase chain reaction and western blot, respectively. Results: β-eudesmol induced expressions of p21 and p53 in mRNA/protein level in HuH28 and HuCCT1 cells. These CCA cells also expressed caspase-3, -8, -9 and bax (mRNA and/or protein level) among others after β-eudesmol treatment indicating its role in both intrinsic and extrinsic caspase-dependent apoptotic pathways. Conclusion: The study demonstrated that β-eudesmol induced the expression of apoptosis pathway proteins, suggesting its potential role in promoting the caspase-dependent apoptotic pathway, and induction of the cell cycle arrest in CCA cell lines. β-eudesmol can be considered as a potential compound for further investigation as an anti-CCA agent. | |||||
書誌情報 |
Journal of Research in Medical Sciences 巻 25, 号 1, p. 7, 発行日 2020-01-20 |
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出版者 | ||||||
出版者 | Wolters Kluwer Medknow Publications | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 17351995 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.4103/jrms.JRMS_291_19 | |||||
権利 | ||||||
権利情報 | c 2020 Journal of Research in Medical Sciences. This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Research in Medical Sciences, 25(1), art.no.7; 2020 |