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Early-phase changes of extravascular lung water index as a prognostic indicator in acute respiratory distress syndrome patients
http://hdl.handle.net/10069/36078
http://hdl.handle.net/10069/36078f56769db-0da4-437c-b3cc-55030902957a
名前 / ファイル | ライセンス | アクション |
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AIC4_27.pdf (593.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2015-12-21 | |||||
タイトル | ||||||
タイトル | Early-phase changes of extravascular lung water index as a prognostic indicator in acute respiratory distress syndrome patients | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Acute lung injury | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Hemodynamics | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Pulmonary edema | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Transpulmonary thermodilution | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Vascular permeability | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Tagami, Takashi
× Tagami, Takashi× Nakamura, Toshiaki× Kushimoto, Shigeki× Tosa, Ryoichi× Watanabe, Akihiro× Kaneko, Tadashi× Fukushima, Hidetada× Rinka, Hiroshi× Kudo, Daisuke× Uzu, Hideaki× Murai, Akira× Takatori, Makoto× Izumino, Hiroo× Kase, Yoichi× Seo, Ryutarou× Takahashi, Hiroyuki× Kitazawa, Yasuhide× Yamaguchi, Junko× Sugita, Manabu× Takahashi, Hiroyuki× Kuroki, Yuichi× Kanemura, Takashi× Morisawa, Kenichiro× Saito, Nobuyuki× Irahara, Takayuki× Yokota, Hiroyuki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: The features of early-phase acute respiratory distress syndrome (ARDS) are leakage of fluid into the extravascular space and impairment of its reabsorption, resulting in extravascular lung water (EVLW) accumulation. The current study aimed to identify how the initial EVLW values and their change were associated with mortality. Methods: This was a post hoc analysis of the PiCCO Pulmonary Edema Study, a multicenter prospective cohort study that included 23 institutions. Single-indicator transpulmonary thermodilution-derived EVLW index (EVLWi) and conventional prognostic factors were prospectively collected over 48 h after enrollment. Associations between 28-day mortality and each variable including initial (on day 0), mean, maximum, and Δ (subtracting day 2 from day 0) EVLWi were evaluated. Results: We evaluated 192 ARDS patients (median age, 69 years (quartile, 24 years); Sequential Organ Failure Assessment (SOFA) score on admission, 10 (5); all-cause 28-day mortality, 31%). Although no significant differences were found in initial, mean, or maximum EVLWi, Δ-EVLWi was significantly higher (i.e., more reduction in EVLWi) in survivors than in non-survivors (3.0 vs. ?0.3 mL/kg, p = 0.006). Age, maximum, and Δ-SOFA scores and Δ-EVLW were the independent predictors for survival according to the Cox proportional hazard model. Patients with Δ-EVLWi > 2.8 had a significantly higher incidence of survival than those with Δ-EVLWi ? 2.8 (log-rank test, χ2 = 7.08, p = 0.008). Conclusions: Decrease in EVLWi during the first 48 h of ARDS may be associated with 28-day survival. Serial EVLWi measurements may be useful for understanding the pathophysiologic conditions in ARDS patients. A large multination confirmative trial is required. | |||||
書誌情報 |
Annals of Intensive Care 巻 4, p. 27, 発行日 2014-08-13 |
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出版者 | ||||||
出版者 | Springer-Verlag GmbH and Co. KG | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 21105820 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1186/s13613-014-0027-7 | |||||
権利 | ||||||
権利情報 | c 2014 Tagami et al.; licensee Springer | |||||
権利 | ||||||
権利情報 | This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Annals of Intensive Care, 4, 27; 2014 |