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The effects of once-weekly teriparatide on hip structure and biomechanical properties assessed by CT
http://hdl.handle.net/10069/34289
http://hdl.handle.net/10069/3428984378724-0b4b-4ad6-ae6d-d09dcd70e639
名前 / ファイル | ライセンス | アクション |
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OI25_1163.pdf (648.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-04-22 | |||||
タイトル | ||||||
タイトル | The effects of once-weekly teriparatide on hip structure and biomechanical properties assessed by CT | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Once-weekly injection | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Osteoporosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Proximal femur geometry | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Quantitative computed tomography | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Teriparatide | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ito, Masako
× Ito, Masako× Oishi, R.× Fukunaga, Masao× Sone, T.× Sugimoto, Toshitsugu× Shiraki, M.× Nishizawa, Y.× Nakamura, Toshitaka |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Once-weekly administration of 56.5 μg teriparatide improved cortical bone parameters and biomechanical parameters at the proximal femur by CT geometry analysis. Introduction: The aim of this study was to evaluate the effects of weekly administration of teriparatide [human PTH (1-34)] on bone geometry, volumetric bone mineral density (vBMD), and parameters of bone strength at the proximal femur which were longitudinally investigated using computed tomography (CT). Methods: The subjects were a subgroup of a recent, randomly assigned, double-blind study (578 subjects) comparing the anti-fracture efficacy of a once-weekly subcutaneous injection of 56.5 μg teriparatide with placebo (TOWER trial). Results: Sixty-six ambulatory postmenopausal women with osteoporosis were enrolled at 15 study sites having multi-detector row CT, and included women injected with teriparatide (n = 29, 74.2 ± 5.1 years) or with placebo (n = 37, 74.8 ± 5.3 years). CT data were obtained at baseline and follow-up scans were performed at 48 and 72 weeks. The data were analyzed to obtain cross-sectional densitometric, geometric, and biomechanical parameters including the section modulus (SM) and buckling ratio (BR) of the femoral neck, inter-trochanter, and femoral shaft. We found that once-weekly teriparatide increased cortical thickness/cross-sectional area (CSA) and total area, and improved biomechanical properties (i.e., decreasing BR) at the femoral neck and shaft. Teriparatide did not change the cortical perimeter. Conclusions: Our longitudinal analysis of proximal femur geometry by CT revealed that once-weekly administration of 56.5 μg teriparatide improved cortical bone parameters at the femoral neck and shaft and also improved biomechanical parameters. | |||||
書誌情報 |
Osteoporosis International 巻 25, 号 3, p. 1163-1172, 発行日 2014-03 |
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出版者 | ||||||
出版者 | Springer London | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0937941X | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14332965 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s00198-013-2596-y | |||||
権利 | ||||||
権利情報 | c The Author(s) 2013. This article is published with open access at Springerlink.com | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Osteoporosis International, 25(3), pp.1163-1172; 2014 |