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Adenine-and-Uridine-rich element RNA-binding factor 1 (AUF1) as an additional marker in human gliomas
http://hdl.handle.net/10069/34695
http://hdl.handle.net/10069/346951ed8dda8-ad42-4075-9e06-17e5f007739f
名前 / ファイル | ライセンス | アクション |
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ActMed59_7.pdf (580.9 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2014-09-09 | |||||
タイトル | ||||||
タイトル | Adenine-and-Uridine-rich element RNA-binding factor 1 (AUF1) as an additional marker in human gliomas | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | glioma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | AUF1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Adenine-and-Uridine rich element | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Haraguchi, Wataru
× Haraguchi, Wataru× Matsuo, Takayuki× Yoshida, Koichi× Nagata, Izumi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | AUF1 is one of Adenine-and-Uridine-rich elements binding protein which regulates the mRNA stability of many genes related to growth regulation, cytokines, and cell cycle-regulatory genes. There was no report about the expression of AUF1 in gliomas. Sections of formalin-fixed, paraffin-embedded tissues from 71 gliomas were stained immunohistochemically using a polyclonal antibody against the adenine-and-uridine-rich element RNA-Binding factor 1 (AUF1) oncoprotein. Positive staining, which is known to correlate with gene amplification, was not associated with patients' sex, age, Karnofsky performance status scores (KPS), tumor size, Bcl-2 expression, or longer overall survival. However, positive staining was negatively correlated with the MIB-1 labeling index, while it was positively correlated with the lower grade group of WHO classification. Expression of the AUF1 oncoprotein appears to be an important additional indicator in human gliomas. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 59, 号 1, p. 7-11, 発行日 2014-07 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | Nagasaki University School of Medicine | |||||
出版者別言語 | ||||||
長崎大学医学部 | ||||||
sortkey | ||||||
2 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia, 59(1), pp.7-11; 2014 |