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The potential benefits of nicaraven to protect against radiation-induced injury in hematopoietic stem/progenitor cells with relative low dose exposures
http://hdl.handle.net/10069/34897
http://hdl.handle.net/10069/34897b204b4f8-42be-419b-93a6-6befc37fb2bb
名前 / ファイル | ライセンス | アクション |
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Supplementary data.pdf (306.8 kB)
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BBRC452_548.pdf (231.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-11-19 | |||||
タイトル | ||||||
タイトル | The potential benefits of nicaraven to protect against radiation-induced injury in hematopoietic stem/progenitor cells with relative low dose exposures | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | DNA repair | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Hematopoietic stem cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Immunomodulation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Inflammatory response | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Nicaraven | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Radiation injury | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ali, Haytham
× Ali, Haytham× Galal, Omima× Urata, Yoshishige× Goto, Shinji× Guo, Chang-Ying× Luo, Lan× Abdelrahim, Eman× Ono, Yusuke× Mostafa, Emtethal× Li, Tao-Sheng |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Nicaraven, a hydroxyl radical-specific scavenger has been demonstrated to attenuate radiation injury in hematopoietic stem cells with 5 Gy γ-ray exposures. We explored the effect and related mechanisms of nicaraven for protecting radiation injury induced by sequential exposures to a relatively lower dose γ-ray. C57BL/6 mice were given nicaraven or placebo within 30 min before exposure to 50 mGy γ-ray daily for 30 days in sequences (cumulative dose of 1.5 Gy). Mice were victimized 24 h after the last radiation exposure, and the number, function and oxidative stress of hematopoietic stem cells were quantitatively estimated. We also compared the gene expression in these purified stem cells from mice received nicaraven and placebo treatment. Nicaraven increased the number of c-kit+ stem/progenitor cells in bone marrow and peripheral blood, with a recovery rate around 60-90% of age-matched non-irradiated healthy mice. The potency of colony forming from hematopoietic stem/progenitor cells as indicator of function was completely protected with nicaraven treatment. Furthermore, nicaraven treatment changed the expression of many genes associated to DNA repair, inflammatory response, and immunomodulation in c-kit+ stem/progenitor cells. Nicaraven effectively protected against damages of hematopoietic stem/progenitor cells induced by sequential exposures to a relatively low dose radiation, via complex mechanisms. | |||||
書誌情報 |
Biochemical and Biophysical Research Communications 巻 452, 号 3, p. 548-553, 発行日 2014-09-26 |
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出版者 | ||||||
出版者 | Academic Press Inc. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0006291X | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.bbrc.2014.08.112 | |||||
権利 | ||||||
権利情報 | c 2014 Elsevier Inc. All rights reserved. | |||||
権利 | ||||||
権利情報 | NOTICE: this is the author’s version of a work that was accepted for publication in Biochemical and Biophysical Research Communications. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Biochemical and Biophysical Research Communications, 452, 3, (2014) | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Biochemical and Biophysical Research Communications, 452(3), pp.548-553; 2014 |