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A Japanese Patient with Lofgren’s Syndrome with an HLA-DR12 Allele and Review of Literature on Japanese Patients
http://hdl.handle.net/10069/34909
http://hdl.handle.net/10069/349092f4908df-dd9b-41ca-8b81-b4aefde87703
名前 / ファイル | ライセンス | アクション |
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TJEM234_137.pdf (653.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-11-26 | |||||
タイトル | ||||||
タイトル | A Japanese Patient with Lofgren’s Syndrome with an HLA-DR12 Allele and Review of Literature on Japanese Patients | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | HLA typing | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Human leukocyte antigen | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Japan | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Lofgren’s syndrome | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Sarcoidosis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ishimatsu, Yuji
× Ishimatsu, Yuji× Koyama, Hanako× Tomonaga, Masaomi× Harada, Tatsuhiko× Nakashima, Shota× Hara, Atsuko× Hara, Shintaro× Kakugawa, Tomoyuki× Sakamoto, Noriho× Hayashi, Tomayoshi× Kohno, Shigeru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Sarcoidosis is a granulomatous disorder of unknown etiology, with several clinical manifestations. Lofgren’s syndrome is an acute type of sarcoidosis, characterized by the triad of arthritis, erythema nodosum, and bilateral hilar lymphadenopathy (BHL), which spontaneously resolve within about 2 years. Lofgren’s syndrome is common among young white women from Nordic countries and Ireland, but it is very rare in Japan. Because the incidence of Lofgren’s syndrome varies according to race, most studies on Lofgren’s syndrome, including HLA typing, have been reported in Western countries. Indeed, HLA-DR3 has been reported to be associated with Lofgren’s syndrome in Western countries, although the association between HLA typing and Japanese Lofgren’s syndrome remains unclear. Here we present a Japanese patient with Lofgren’s syndrome. A 34-year-old female patient was hospitalized with arthritis and erythema nodosum. Chest computed tomography revealed mediastinal and BHL. Endobronchial ultrasound-guided transbronchial needle aspiration showed non-caseating epithelioid cell granulomas. Lofgren’s syndrome was thus diagnosed. Her ankle arthralgia and bilateral ankle swelling recovered without steroid treatment within two months, and the BHL almost completely diminished one year after admission. Her HLA genotype contains DR12. We also reviewed the literature on 11 Japanese patients with Lofgren’s syndrome, showing that HLA-DR12 is present in fve out of nine patients (55.6%). The relevant data were unavailable in the remaining three patients. Importantly, only 5.4% of registered donors in the Japan Marrow Donor Program are positive for this allele. We suggest the potential link between HLA-DR12 and the pathogenesis of Lofgren’s syndrome in Japanese patients. | |||||
書誌情報 |
The Tohoku Journal of Experimental Medicine 巻 234, 号 2, p. 137-141, 発行日 2014-09-30 |
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出版者 | ||||||
出版者 | 東北ジャーナル刊行会 | |||||
出版者別言語 | ||||||
Tohoku University Medical Press | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00408727 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13493329 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1620/tjem.234.137 | |||||
権利 | ||||||
権利情報 | c 2014 Tohoku University Medical Press | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The Tohoku Journal of Experimental Medicine, 234(2), pp.137-141; 2014 |