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Influence of antimicrobial regimen on decreased in-hospital mortality of patients with MRSA bacteremia
http://hdl.handle.net/10069/34970
http://hdl.handle.net/10069/3497087fd25f8-f238-42f2-9c83-57a2f8b59453
名前 / ファイル | ライセンス | アクション |
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JIC20_350.pdf (898.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-12-25 | |||||
タイトル | ||||||
タイトル | Influence of antimicrobial regimen on decreased in-hospital mortality of patients with MRSA bacteremia | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Bacteremia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Methicillin-resistant Staphylococcus aureus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | MIC | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Mortality | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | SCCmec | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kaku, Norihito
× Kaku, Norihito× Yanagihara, Katsunori× Morinaga, Yoshitomo× Yamada, Koichi× Harada, Yosuke× Migiyama, Yohei× Nagaoka, Kentaro× Matsuda, Jun-ichi× Uno, Naoki× Hasegawa, Hiroo× Miyazaki, Taiga× Izumikawa, Koichi× Kakeya, Hiroshi× Yamamoto, Yoshihiro× Kohno, Shigeru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most important causes of bacteremia. Recently, several epidemiological and microbiological changes have become evident in MRSA infections. The purposes of this study were to assess clinical characteristics of patients with MRSA bacteremia and microbiological changes in MRSA. We conducted a retrospective observational study on patients with MRSA bacteremia who were hospitalized between 2008 and 2011. We used univariate and multivariate analysis to evaluate the predictors associated with 30-day mortality. The 7-day and 30-day mortality rates were 12.0% and 25.3%, respectively. According to multivariate analysis, the independent predictors that associated with 30-day mortality were leukopenia, low serum albumin, high sequential organ failure assessment (SOFA) score, and quinolone use within 30 days. Compared to previous data (2003-2007), the SOFA score of the new data set remained unchanged, but in-hospital mortality decreased significantly. In particular, the mortality associated with use of vancomycin (VCM) was significantly lower. Although the minimuminhibitory concentration of VCM required to inhibit the growth of 90% of organisms (MIC90) had not changed, the trough value of VCM changed significantly; a VCM trough value of 10 or greater was significantly higher compared to previous data. Of the staphylococcal cassette chromosome mec (SCCmec) types, SCCmec II values decreased significantly, and SCCmec I and IV values increased significantly. Our results indicate that changes in VCM usage might contribute to decreased in-hospital mortality. | |||||
書誌情報 |
Journal of Infection and Chemotherapy 巻 20, 号 6, p. 350-355, 発行日 2014-06 |
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出版者 | ||||||
出版者 | 日本化学療法学会・日本感染症学会 | |||||
出版者別言語 | ||||||
Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1341321X | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.jiac.2013.12.009 | |||||
権利 | ||||||
権利情報 | c 2014, Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. | |||||
権利 | ||||||
権利情報 | NOTICE: this is the author’s version of a work that was accepted for publication in Journal of Infection and Chemotherapy. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Infection and Chemotherapy, 20, 6, (2014) | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Infection and Chemotherapy, 20(6), pp.350-355; 2014 |