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Pathogenesis and clinical features of chronic pulmonary aspergillosis ? Is it possible to distinguish CNPA and CCPA clinically?
http://hdl.handle.net/10069/34973
http://hdl.handle.net/10069/34973dee6bec4-2403-4d80-8c65-8053cfa3eba4
名前 / ファイル | ライセンス | アクション |
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JIC20_208.pdf (825.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-12-25 | |||||
タイトル | ||||||
タイトル | Pathogenesis and clinical features of chronic pulmonary aspergillosis ? Is it possible to distinguish CNPA and CCPA clinically? | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Chronic cavitary pulmonary aspergillosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Chronic necrotizing pulmonary aspergillosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Chronic progressive pulmonary aspergillosis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Izumikawa, Koichi
× Izumikawa, Koichi× Tashiro, Takayoshi× Tashiro, Masato× Takazono, Takahiro× Kosai, Kosuke× Morinaga, Yoshitomo× Kurihara, Shintaro× Nakamura, Shigeki× Imamura, Yoshifumi× Miyazaki, Taiga× Tsukamoto, Misuzu× Kakeya, Hiroshi× Hayashi, Tomayoshi× Yanagihara, Katsunori× Nagayasu, Takeshi× Kohno, Shigeru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: The pathogenesis of chronic pulmonary aspergillosis (CPA) including chronic necrotizing pulmonary aspergillosis (CNPA), chronic cavitary pulmonary aspergillosis (CCPA), and simple aspergilloma (SA) has been poorly investigated. We examined all types of CPA cases with histopathological evidence to clarify the differences in pathogenesis and clinical features. Method: We searched for cases diagnosed as pulmonary aspergillosis by histopathological examination in Nagasaki University Hospital between 1964 and September 2010. All available clinical information including radiological findings were collected and analyzed. Result: We found 7, 5, 8, and 7 cases of proven CNPA, probable CNPA, CCPA, and SA, respectively. The radiograph of proven and probable CNPA was initially infiltrates or nodules that progress to form cavities with or without aspergilloma, whereas the radiograph of CCPA showed pre-existed cavities and pericavitary infiltrates with or without aspergilloma. The patients with proven and probable CNPA exhibited not only respiratory symptoms but also systemic symptoms and malnutrition. Aspergillus fumigatus was the most frequently isolated Aspergillus species (n = 14), however, Aspergillus niger was the predominant isolated species in proven CNPA cases (n = 4). Conclusion: Our data indicate that the cases with chronic infiltration, progressive cavitation, and subsequent aspergilloma formation should be diagnosed as CNPA, and the cases with pre-existed cavities showing peri-cavitary infiltrates with or without aspergilloma would mean CCPA. However, it may be difficult to distinguish the two subtypes if a series of adequate radiography films are not available. We propose the term "chronic progressive pulmonary aspergillosis (CPPA)" for the clinical syndrome including both CNPA and CCPA. | |||||
書誌情報 |
Journal of Infection and Chemotherapy 巻 20, 号 3, p. 208-212, 発行日 2014-03 |
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出版者 | ||||||
出版者 | 日本化学療法学会・日本感染症学会 | |||||
出版者別言語 | ||||||
Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1341321X | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.jiac.2013.10.016 | |||||
権利 | ||||||
権利情報 | c 2013, Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. | |||||
権利 | ||||||
権利情報 | NOTICE: this is the author’s version of a work that was accepted for publication in Journal of Infection and Chemotherapy. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Infection and Chemotherapy, 20, 3, (2014) | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Infection and Chemotherapy, 20(3), pp.208-212; 2014 |