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Life-threatening toxicity in a patient with UGT1A1*6 heterozygous polymorphism after irinotecan-based chemotherapy: a case report
http://hdl.handle.net/10069/34980
http://hdl.handle.net/10069/3498068dd8aec-20d5-4caa-a288-b9fe474f9e7a
名前 / ファイル | ライセンス | アクション |
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ActMed59_63.pdf (458.2 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2014-12-26 | |||||
タイトル | ||||||
タイトル | Life-threatening toxicity in a patient with UGT1A1*6 heterozygous polymorphism after irinotecan-based chemotherapy: a case report | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | UGT1A1*6 polymorphism | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | irinotecan | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | lung cancer | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Ogawara, Daiki
× Ogawara, Daiki× Fukuda, Minoru× Nakamura, Yoichi× Nakatomi, Katsumi× Motoshima, Kohei× Senju, Hiroaki× Mizoguchi, Kousuke× Takemoto, Shinnosuke× Honda, Takuya× Ashizawa, Kazuto× Hasegawa, Yoshinori× Kohno, Shigeru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Polymorphism of the UGT1A1 gene is known to play an important role in irinotecan pharmacokinetics and severe toxicity. A 71-year-old man with lung cancer (squamous cell carcinoma cT2aN3M0 stage IIIB) received irinotecan and cisplatin with concurrent thoracic radiotherapy. Although all treatments were discontinued after day 7, severe leukopenia, neutropenia, febrile neutropenia, thrombocytopenia, and diarrhea developed. His life was at risk, and his ECOG performance status (PS) fell to 4. He had UGT1A1*6 heterozygous and UGT1A1*28 wild-type gene polymorphisms. Considering its frequency in Asians, we should take care when using irinotecan to treat patients with UGT1A1*6 heterozygous polymorphism. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 59, 号 2, p. 63-65, 発行日 2014-12 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | Nagasaki University School of Medicine | |||||
出版者別言語 | ||||||
長崎大学医学部 | ||||||
sortkey | ||||||
4 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia, 59(2), pp.63-65; 2014 |