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Determination of the ratio between mercaptalbumin and nonmercaptalbumin by HPLC with fluorescence probe specifically binding to albumin
http://hdl.handle.net/10069/33940
http://hdl.handle.net/10069/339406b7b617c-10f5-45d7-9ba8-4549f7ad6a82
名前 / ファイル | ライセンス | アクション |
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JPBA88_170.pdf (883.9 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-11-05 | |||||
タイトル | ||||||
タイトル | Determination of the ratio between mercaptalbumin and nonmercaptalbumin by HPLC with fluorescence probe specifically binding to albumin | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 4-[4-(4-dimethylaminophenyl)-5-phenyl-1H-imidazol-2-yl]Benzoic acid methyl ester | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Fluorescence probe | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Mercaptalbumin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Nonmercaptalbumin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Redox state | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ohyama, Kaname
× Ohyama, Kaname× Kishikawa, Naoya× Matsuo, Aya× Imazato, Takahiro× Ueki, Yukitaka× Wada, Mitsuhiro× Nakashima, Kenichiro× Kuroda, Naotaka |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | A simple and selective HPLC-fluorescence (FL) method with FL probe, 4-[4-(4-dimethylaminophenyl)-5-phenyl-1. H-imidazol-2-yl]benzoic acid methyl ester (DAPIM), for simultaneous determination of mercaptalbumin (HMA) and nonmercaptalbumin (HNA1) was developed. After HMA and HNA1 were separated on an ion-exchange column, they were on-line and post-column mixed with DAPIM. The DAPIM-albumin complex produces FL (λex 370. nm and λem 510. nm); however, DAPIM solution never gives the FL. Based on this mechanism, selective determination of HMA and HNA1 were achieved without any pretreatment and interfering peak. The proposed method was applied to the measurement of HMA and HNA1 in human serum of healthy volunteers and diabetes mellitus patients. | |||||
書誌情報 |
Journal of Pharmaceutical and Biomedical Analysis 巻 88, p. 170-173, 発行日 2014-01-25 |
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出版者 | ||||||
出版者 | Elsevier | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 07317085 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.jpba.2013.08.009 | |||||
権利 | ||||||
権利情報 | © 2013 Elsevier B.V. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Pharmaceutical and Biomedical Analysis, 88, pp.170-173; 2014 |