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The aims of this study were to establish a PF model in rats and to investigate the efficacy of our new method for preventing PF, which utilizes myoblast sheets made using tissue engineering techniques. Methods: To establish a PF model, the rats underwent transection of each of four pancreatic ducts: the gastric, duodenal, common, and splenic ducts, respectively. Their ascitic amylase and lipase levels were then measured. To investigate the efficacy of myoblast sheets at preventing PF, a myoblast sheet was attached to the pancreatic stump in the PF models. The levels of amylase and lipase in both serum and ascites were then measured, and surgical specimens were investigated pathologically. Results: The new PF model established by transecting the splenic duct in rats may prove very useful. There were no significant differences in serum amylase and lipase levels between the myoblast sheet (+) group and the sheet (-) group. 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Development of a novel rat model with pancreatic fistula and the prevention of this complication using tissue-engineered myoblast sheets
http://hdl.handle.net/10069/33983
http://hdl.handle.net/10069/33983a66156c2-e285-485b-babb-e71358d71525
名前 / ファイル | ライセンス | アクション |
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JouGas48_1081.pdf (1.3 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-10-01 | |||||
タイトル | ||||||
タイトル | Development of a novel rat model with pancreatic fistula and the prevention of this complication using tissue-engineered myoblast sheets | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Myoblast sheet | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Pancreatic fistula | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Rat model | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Tissue engineering | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Tanaka, Takayuki
× Tanaka, Takayuki× Kuroki, Tamotsu× Adachi, Tomohiko× Ono, Shinichiro× Kitasato, Amane× Hirabaru, Masataka× Takatsuki, Mitsuhisa× Eguchi, Susumu |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: Pancreatic fistula (PF) is one of the most important complications of pancreatic surgery. The aims of this study were to establish a PF model in rats and to investigate the efficacy of our new method for preventing PF, which utilizes myoblast sheets made using tissue engineering techniques. Methods: To establish a PF model, the rats underwent transection of each of four pancreatic ducts: the gastric, duodenal, common, and splenic ducts, respectively. Their ascitic amylase and lipase levels were then measured. To investigate the efficacy of myoblast sheets at preventing PF, a myoblast sheet was attached to the pancreatic stump in the PF models. The levels of amylase and lipase in both serum and ascites were then measured, and surgical specimens were investigated pathologically. Results: The new PF model established by transecting the splenic duct in rats may prove very useful. There were no significant differences in serum amylase and lipase levels between the myoblast sheet (+) group and the sheet (-) group. However, there were significant differences in ascitic amylase and lipase levels between the two groups (p < 0.05). Among the pathological findings, the number of inflammatory cells in the myoblast sheet group was smaller than that in the control group. In addition, the presence of the myoblast sheets on the surface of the pancreatic stump was confirmed by immunofluorescence staining. Conclusion: Our data demonstrate the efficacy of the new rat model of PF presented herein, and that it might be possible to prevent PF using myoblast sheets. | |||||
書誌情報 |
Journal of Gastroenterology 巻 48, 号 9, p. 1081-1089, 発行日 2013-09 |
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出版者 | ||||||
出版者 | 日本消化器病学会 | |||||
出版者別言語 | ||||||
Japanese Society of Gastroenterology | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09441174 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14355922 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s00535-012-0706-9 | |||||
権利 | ||||||
権利情報 | © The Japanese Society of Gastroenterology. | |||||
権利 | ||||||
権利情報 | The final publication is available at www.springerlink.com | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Gastroenterology, 48(9), pp.1081-1089; 2013 |