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Antxr1, Which is a Target of Runx2, Regulates Chondrocyte Proliferation and Apoptosis
http://hdl.handle.net/10069/39888
http://hdl.handle.net/10069/39888c41ca65e-47d2-46fb-82dd-ecb30a484cbb
名前 / ファイル | ライセンス | アクション |
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IJMS21_2425.pdf (8.5 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-04-24 | |||||
タイトル | ||||||
タイトル | Antxr1, Which is a Target of Runx2, Regulates Chondrocyte Proliferation and Apoptosis | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Antxr1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Runx2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | GAPO syndrome | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | chondrocyte proliferation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | apoptosis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Jiang, Qing
× Jiang, Qing× Qin, Xin× Yoshida, Carolina Andrea× Komori, Hisato× Yamana, Kei× Ohba, Shinsuke× Hojo, Hironori× Croix, Brad St.× Kawata-Matsuura, Viviane K. S.× Komori, Toshihisa |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Antxr1/Tem8 is highly expressed in tumor endothelial cells and is a receptor for anthrax toxin. Mutation of Antxr1 causes GAPO syndrome, which is characterized by growth retardation, alopecia, pseudo-anodontia, and optic atrophy. However, the mechanism underlying the growth retardation remains to be clarified. Runx2 is essential for osteoblast di erentiation and chondrocyte maturation and regulates chondrocyte proliferation through Ihh induction. In the search of Runx2 target genes in chondrocytes, we found that Antxr1 expression is upregulated by Runx2. Antxr1 was highly expressed in cartilaginous tissues and was directly regulated by Runx2. In skeletal development, the process of endochondral ossification proceeded similarly in wild-type and Antxr1?/? mice. However,the limbs of Antxr1?/? mice were shorter than those of wild-type mice from embryonic day 16.5 due to the reduced chondrocyte proliferation. Chondrocyte-specific Antxr1 transgenic mice exhibited shortened limbs, although the process of endochondral ossification proceeded as in wild-type mice.BrdU-uptake and apoptosis were both increased in chondrocytes, and the apoptosis-high regions were mineralized. These findings indicated that Antxr1, of which the expression is regulated by Runx2, plays an important role in chondrocyte proliferation and that overexpression of Antxr1 causes chondrocyte apoptosis accompanied by matrix mineralization. |
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書誌情報 |
International Journal of Molecular Sciences 巻 21, 号 7, p. 2425, 発行日 2020-03-31 |
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出版者 | ||||||
出版者 | MDPI | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 16616596 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14220067 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3390/ijms21072425 | |||||
権利 | ||||||
権利情報 | c 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | International journal of molecular sciences, 21(7), 2425; 2020 |