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Mesenchymal Stem Cell Therapy for Cutaneous Radiation Syndrome
http://hdl.handle.net/10069/31916
http://hdl.handle.net/10069/31916f976e8fd-a87f-4eb6-bc7a-c47fb6b59b73
名前 / ファイル | ライセンス | アクション |
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HealPhy98_858.pdf (757.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-05-22 | |||||
タイトル | ||||||
タイトル | Mesenchymal Stem Cell Therapy for Cutaneous Radiation Syndrome | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Exposure | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Radiation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Radiation damage | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Radiotherapy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | World Health Organization | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Akita, Sadanori
× Akita, Sadanori× Akino, Kozo× Hirano, Akiyoshi× Ohtsuru, Akira× Yamashita, Shunichi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Systemic and local radiation injuries caused by nuclear power reactor accidents, therapeutic irradiation, or nuclear terrorism should be prevented or properly treated in order to improve wound management and save lives. Currently, regenerative surgical modalities should be attempted with temporal artificial dermis impregnated and sprayed with a local angiogenic factor such as basic fibroblast growth factor, and secondary reconstruction can be a candidate for demarcation and saving the donor morbidity. Human mesenchymal stem cells and adipose-derived stem cells, together with angiogenic and mitogenic factor of basic fibroblast growth factor and an artificial dermis, were applied over the excised irradiated skin defect and were tested for differentiation and local stimulation effects in the radiation-exposed wounds. The perforator flap and artificial dermal template with growth factor were successful for reconstruction in patients who were suffering from complex underlying disease. Patients were uneventfully treated with minimal morbidities. In the experiments, the hMSCs are strongly proliferative even after 20 Gy irradiation in vitro. In vivo, 4 Gy rat whole body irradiation demonstrated that sustained marrow stromal (mesenchymal stem) cells survived in the bone marrow. Immediate artificial dermis application impregnated with cells and the cytokine over the 20 Gy irradiated skin and soft tissues demonstrated the significantly improved fat angiogenesis, architected dermal reconstitution, and less inflammatory epidermal recovery. Detailed understanding of underlying diseases and rational reconstructive procedures brings about good outcomes for difficult irradiated wound healing. Adipose-derived stem cells are also implicated in the limited local injuries for short cell harvesting and processing time in the same subject. | |||||
書誌情報 |
Health Physics 巻 98, 号 6, p. 858-862, 発行日 2010-06 |
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出版者 | ||||||
出版者 | Lippincott Williams and Wilkins | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00179078 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1097/HP.0b013e3181d3d52c | |||||
権利 | ||||||
権利情報 | © 2010 Health Physics Society. | |||||
権利 | ||||||
権利情報 | This is a non-final version of an article published in final form in Health Physics, 98(6), pp.858-862; 2010 | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Health Physics, 98(6), pp.858-862; 2010 |