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Effects of fish collagen peptides on collagen post-translational modifications and mineralization in an osteoblastic cell culture system
http://hdl.handle.net/10069/32116
http://hdl.handle.net/10069/321167e4d7232-aec6-4328-b35d-34d48c71f375
名前 / ファイル | ライセンス | アクション |
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DMJ32_88.pdf (1.6 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-06-04 | |||||
タイトル | ||||||
タイトル | Effects of fish collagen peptides on collagen post-translational modifications and mineralization in an osteoblastic cell culture system | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Collagen cross-link | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Collagen post-translational modification | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Fish collagen peptides | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Maturation of collagen | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Mineralization | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yamada, Shizuka
× Yamada, Shizuka× Nagaoka, Hideaki× Terajima, Masahiko× Tsuda, Nobuaki× Hayashi, Yoshihiko× Yamauchi, Mitsuo |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Collagen is one of the most widely used biomaterials for tissue engineering and regenerative medicine. Fish collagen peptides (FCP) have been used as a dietary supplement, but their effects on the cellular function are still poorly understood. The objective of this study was to investigate the effects of FCP on collagen synthesis, quality and mineralization using an osteoblastic MC3T3-E1 cell culture system. Cells treated with FCP significantly upregulated the gene expression of several collagen modifying enzymes and more collagen was deposited in the cultures. Collagen in the treated group showed a greater extent of lysine hydroxylation, higher levels of hydroxylysine-aldehyde derived cross-links and accelerated cross-link maturation compared with the untreated group. Furthermore, the treated group showed accelerated matrix mineralization. These results indicate that FCP exerts a positive effect on osteoblastic cells in terms of collagen synthesis, quality and mineralization, thereby suggesting the potential utility of FCP for bone tissue engineering. | |||||
書誌情報 |
Dental Materials Journal 巻 32, 号 1, p. 88-95, 発行日 2013-02-01 |
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出版者 | ||||||
出版者 | 日本歯科理工学会 | |||||
出版者別言語 | ||||||
Japanese Society for Dental Materials and Devices | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 02874547 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 18811361 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.4012/dmj.2012-220 | |||||
権利 | ||||||
権利情報 | © 2013 The Japanese Society for Dental Materials and Devices | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Dental Materials Journal, 32(1), pp.88-95; 2013 |