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Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness
http://hdl.handle.net/10069/32219
http://hdl.handle.net/10069/322191e881b1e-a384-4f23-ad1b-0b5909db5979
名前 / ファイル | ライセンス | アクション |
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CSC12_487.pdf (5.4 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-06-10 | |||||
タイトル | ||||||
タイトル | Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kondo, Takayuki
× Kondo, Takayuki× Asai, Masashi× Tsukita, Kayoko× Kutoku, Yumiko× Ohsawa, Yutaka× Sunada, Yoshihide× Imamura, Keiko× Egawa, Naohiro× Yahata, Naoki× Okita, Keisuke× Takahashi, Kazutoshi× Asaka, Isao× Aoi, Takashi× Watanabe, Akira× Watanabe, Kaori× Kadoya, Chie× Nakano, Rie× Watanabe, Dai× Maruyama, Kei× Hori, Osamu× Hibino, Satoshi× Choshi, Tominari× Nakahata, Tatsutoshi× Hioki, Hiroyuki× Kaneko, Takeshi× Naitoh, Motoko× Yoshikawa, Katsuhiro× Yamawaki, Satoko× Suzuki, Shigehiko× Hata, Ryuji× Ueno, Shu-ichi× Seki, Tsuneyoshi× Kobayashi, Kazuhiro× Toda, Tatsushi× Murakami, Kazuma× Irie, Kazuhiro× Klein, William L.× Mori, Hiroshi× Asada, Takashi× Takahashi, Ryosuke× Iwata, Nobuhisa× Yamanaka, Shinya× Inoue, Haruhisa |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Oligomeric forms of amyloid-β peptide (Aβ) are thought to play a pivotal role in the pathogenesis of Alzheimer's disease (AD), but the mechanism involved is still unclear. Here, we generated induced pluripotent stem cells (iPSCs) from familial and sporadic AD patients and differentiated them into neural cells. Aβ oligomers accumulated in iPSC-derived neurons and astrocytes in cells from patients with a familial amyloid precursor protein (APP)-E693Δ mutation and sporadic AD, leading to endoplasmic reticulum (ER) and oxidative stress. The accumulated Aβ oligomers were not proteolytically resistant, and docosahexaenoic acid (DHA) treatment alleviated the stress responses in the AD neural cells. Differential manifestation of ER stress and DHA responsiveness may help explain variable clinical results obtained with the use of DHA treatment and suggests that DHA may in fact be effective for a subset of patients. It also illustrates how patient-specific iPSCs can be useful for analyzing AD pathogenesis and evaluating drugs. | |||||
書誌情報 |
Cell Stem Cell 巻 12, 号 4, p. 487-496, 発行日 2013-04-04 |
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出版者 | ||||||
出版者 | Cell Press | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 19345909 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.stem.2013.01.009 | |||||
権利 | ||||||
権利情報 | © 2013 Elsevier Inc. | |||||
権利 | ||||||
権利情報 | NOTICE: this is the author’s version of a work that was accepted for publication in Cell Stem Cell. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Cell Stem Cell, 12, 4(2013) | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Cell Stem Cell, 12(4), pp.487-496; 2013 |