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Pharmacogenetics of human ABC transporter ABCC11: new insights into apocrine gland growth and metabolite secretion
http://hdl.handle.net/10069/32549
http://hdl.handle.net/10069/325499d9ecc5f-83ed-4b61-afd4-b1bfc29f0371
名前 / ファイル | ライセンス | アクション |
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FroGen3_306.pdf (1.8 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-07-01 | |||||
タイトル | ||||||
タイトル | Pharmacogenetics of human ABC transporter ABCC11: new insights into apocrine gland growth and metabolite secretion | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 5-fluorouracil | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Apocrine gland | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Axillary osmidrosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Breast cancer | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Earwax | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Mastopathy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Tamoxifen | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ishikawa, Toshihisa
× Ishikawa, Toshihisa× Toyoda, Yu× Yoshiura, Koh-ichiro× Niikawa, Norio |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Cell secretion is an important physiological process that ensures smooth metabolic activities and tissue repair as well as growth and immunological functions in the body. Apocrine secretion occurs when the secretory process is accomplished with a partial loss of cell cytoplasm. The secretory materials are contained within secretory vesicles and are released during secretion as cytoplasmic fragments into the glandular lumen or interstitial space. The recent finding that the non-synonymous single nucleotide polymorphisms (SNP) 538G > A (rs17822931; Gly180Arg) in the ABCC11 gene determines the type of earwax in humans has shed light on the novel function of this ABC (ATP-binding cassette) transporter in apocrine glands. The wild-type (Gly180) of ABCC11 is associated with wet-type earwax, axillary osmidrosis, and colostrum secretion from the mammary gland as well as the potential risk of mastopathy. Furthermore, the SNP (538G > A) in the ABCC11 gene is suggested to be a clinical biomarker for the prediction of chemotherapeutic efficacy. The aim of this review article is to provide an overview on the discovery and characterization of genetic polymorphisms in the human ABCC11 gene and to explain the impact of ABCC11 538G > A on the apocrine phenotype as well as the anthropological aspect of this SNP in the ABCC11 gene and patients’ response to nucleoside-based chemotherapy. | |||||
書誌情報 |
Frontiers in Genetics 巻 3, p. 306, 発行日 2013-01-02 |
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出版者 | ||||||
出版者 | Frontiers Media S.A. | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 16648021 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3389/fgene.2012.00306 | |||||
権利 | ||||||
権利情報 | © 2013 Ishikawa, Toyoda, Yoshiura and Niikawa. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Frontiers in Genetics, 3, Article 306; 2013 |