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Bronchoalveolar lavage galactomannan for the diagnosis of chronic pulmonary aspergillosis
http://hdl.handle.net/10069/30850
http://hdl.handle.net/10069/308502b7f1a56-42e5-4504-ac93-46fbe38526ef
名前 / ファイル | ライセンス | アクション |
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MedMyc87_811.pdf (142.5 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-12-01 | |||||
タイトル | ||||||
タイトル | Bronchoalveolar lavage galactomannan for the diagnosis of chronic pulmonary aspergillosis | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Aspergillosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Bronchoalveolar lavage | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Chronic | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Galactomannan | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Pulmonary | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Izumikawa, Koichi
× Izumikawa, Koichi× Yamamoto, Yoshihiro× Mihara, Tomo× Takazono, Takahiro× Morinaga, Yoshitomo× Kurihara, Shintaro× Nakamura, Shigeki× Imamura, Yoshifumi× Miyazaki, Taiga× Nishino, Tomoya× Tsukamoto, Misuzu× Kakeya, Hiroshi× Yanagihara, Katsunori× Mine, Mariko× Yasuoka, Akira× Tashiro, Takayoshi× Kohno, Shigeru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Diagnosing chronic pulmonary aspergillosis (CPA) is complicated, and there are limited data available regarding the identification of galactomannan (GM) in clinical specimens to assist the detection of this infection. The purpose of this study was to evaluate the detection of GM in bronchoalveolar lavage fluid (BALF) and serum and to assess its utility for diagnosing CPA. We retrospectively reviewed the diagnostic and clinical characteristics of 144 patients, with and without CPA, in Nagasaki University Hospital, Japan, whose BAL and serum specimens were examined for the presence of GM. The Platelia Aspergillus enzyme immunoassay (PA EIA) was performed according to the manufacturer's instructions. The mean values of BALF GM antigen were 4.535 (range, 0.06214.120) and 0.430 (range, 0.0629.285) in CPA (18) and non-CPA (126) patients, respectively. The mean values of serum GM antigen were 1.557 (range, 0.2325.397) and 0.864 (range, 0.0288.956) in CPA and non-CPA patients, respectively. PA EIA of BALF is superior to the test with serum, with the optimal cut-off values for BALF and serum of 0.4 and 0.7, respectively. The sensitivity and specificity of PA EIA in BALF at a cut-off of 0.4 were 77.2% and 77.0%, respectively, whereas with serum at a cut-off of 0.7, they were 66.7% and 63.5%, respectively. GM testing using BALF showed reasonable sensitivity and specificity as compared to that using serum. Thus, assessing GM levels in BALF may enhance the accuracy of diagnosing CPA. | |||||
書誌情報 |
Medical Mycology 巻 50, 号 8, p. 811-817, 発行日 2012-11 |
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出版者 | ||||||
出版者 | Informa Healthcare | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13693786 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14602709 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3109/13693786.2012.682228 | |||||
権利 | ||||||
権利情報 | © 2012 ISHAM. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Medical Mycology, 50(8), pp.811-817; 2012 |